#4618
The exceptionally rare phenomenon of well-differentiated colon neuroendocrine tumours
Introduction:
Colonic neuroendocrine tumours (NETs), excluding rectal NETs, are often described as relatively common and aggressive, with inferior median survival compared to other gastrointestinal (GI) primary sites. However, epidemiological databases may conflate well-differentiated NETs with poorly differentiated NECs, leading to unclear data on prevalence, clinical behaviour, and prognosis of well-differentiated colonic NETs.
Conference:
Presenting Author:
Al-Toubah T
Authors:
Al-Toubah T,
Strosberg J,
Keywords:
colon,
neuroendocrine tumour,
caecum,
sigmoid,
neuroendocrine neoplasm,
#1495
Everolimus for Advanced, Progressive, Nonfunctional Neuroendocrine Tumors (NET) of the Gastrointestinal (GI) Tract: Efficacy and Safety from a RADIANT-4 Subgroup Analysis
Introduction:
Everolimus (EVE) demonstrated progression-free survival (PFS) benefit of 7.1 months compared to placebo in the phase 3 RADIANT-4 study in patients (pts) with advanced, well-differentiated, progressive, nonfunctional NET.
Conference:
13th Annual ENETSConcerence (2016)
Presenting Author:
Singh S
Authors:
Singh S,
Carnaghi C,
Buzzoni R,
Raderer M,
Lahner H,
Keywords:
Everolimus,
progression-free survival,
gastrointestinal NET,
#1490
Even Malignant Appendiceal Neuroendocrine Tumors Exhibit No Recurrent Chromosomal Alterations
Introduction:
Neuroendocrine tumors (NETs) of the midgut are located in the ileum (iNET), caecum or appendix (aNET). Despite of the similar origin, NETs of the ileum and the appendix behave remarkably different. iNETs show high malignant potential, which manifests with early lymph node or liver metastases. Genetically, the loss of chromosome 18 (Ch18) in 60-74% of cases is the most frequent alteration in iNETs. aNETs are often incidental findings, rarely show metastases, and no chromosomal alterations are known.
Conference:
13th Annual ENETSConcerence (2016)
Presenting Author:
Sipos B
Authors:
Nann D,
Nieser M,
Sperveslage J,
Henopp T,
Vokuhl C,
Keywords:
NET,
