Abstract Library

#4465 RET Lys666Asn has low MEN2-related tumours penetrance but may be associated with pheochromocytoma

Introduction: Multiple Endocrine Neoplasia type 2 (MEN2) is caused by germline pathogenic variants (PVs) in the RET proto-oncogene, leading to medullary thyroid carcinoma (MTC), pheochromocytoma, and primary hyperparathyroidism (PHPT). RET c.1998G>C, p.Lys666Asn is a rare PV, with 33 cases described thus far, and is associated with low penetrance of MEN2-related tumours, but its clinical significance remains incompletely understood.

Conference:

Presenting Author: Halperin R

Authors: Halperin R, Peshes-Yaloz N, Tirosh A, Twito O,

Keywords: MEN2, pheochromocytoma, hyperparathyroidism, medullary thyroid carcinoma,

#4106 Overview of 609 cases of neuroendocrine neoplasms

Introduction: Neuroendocrine neoplasms are rare tumors that originate from peptideric neurons and neuroendocrine cells, have neuroendocrine functions and express neuroendocrine markers, and early identification and treatment can significantly improve the prognosis of patients.

Conference:

Presenting Author: Yingmei T

Authors: Dai C,

Keywords: neuroendocrine neoplasm, clinical manifestation, auxiliary examination, treatment,

#4101 Pulmonary neuroendocrine tumors – Symptomatology, tumor characteristics, treatment strategies, and long-term outcomes in 37 Patients

Introduction: Pulmonary Neuroendocrine Tumors (NET) constitute a complex group of diseases with varied clinical manifestations and no definitive diagnostic and treatment guidelines.

Conference:

Presenting Author: Krishna B

Authors: Jain D, Eshpuniyani P, Deshpande R, Sharma S, Krishna B,

Keywords: epidemiology, pulmonary NET, lobectomy, prognosis,

#4098 A case of functional pancreatic neuroendocrine tumor with hypercalcemia as the main manifestation

Introduction: NEN is a type of rare neoplasm originated from peptidenergic neurons and neuroendocrine cells. Even for functional neuroendocrine tumors, the hormones secreted can be temporally and spatially heterogeneous. Hypercalcemia being a rare clinical manifestation of F-pNEN.

Conference:

Presenting Author: Yingmei T

Authors: Yanping Z, Yingmei T, Jieting D,

Keywords: pancreatic neuroendocrine tumor, functional, parathyroid hormone related peptide,

#4067 Malignancy of gastric neuroendocrine tumors is higher than pancreatic neuroendocrine tumors in Chinese population – Characterisation and analysis of factors

Introduction: Based on a large-scale epidemiological survey with a total of 2010 cases of neuroendocrine tumors (NENs) in the Chinese population from multiple centers, we observed that the malignancy of gastric NENs (G3, accounting for 67.2%) is higher than that of pancreatic NENs(G3, accounting for 9.9%).

Conference:

Presenting Author: Sun W

Authors: Sun W, Fan J,

Keywords: gastric NEN, pancreatic NEN, epidemiology, multi-center,