#4609
External validation of Rachel score: A prognostic tool for lung neuroendocrine tumours
Introduction:
Lung NETs are a heterogeneous group of tumours with variegated clinical presentation and course. The histological subtype (TC vs AC) and TNM stage are established prognostic factors. In a previous work by our group, we developed a prognostic model named Rachel score, with a satisfactory ability to predict OS and PFS in this population.
Conference:
Presenting Author:
La Salvia A
Authors:
La Salvia A,
Marcozzi B,
Lamberti G,
Manai C,
Mazzilli R,
Keywords:
lung neuroendocrine tumour,
prognostic tool,
Rachel score,
external cohort,
validation,
#3521
Molecular, histopathological, and functional characterization of the dysregulation of the splicing machinery in lung carcinoids
Introduction:
Alteration of alternative splicing is an emerging hallmark of cancer, which has been linked to aggressiveness features in diverse types of tumors, including neuroendocrine neoplasms.
Conference:
Presenting Author:
García Vioque V
Authors:
García-Vioque V,
Blázquez-Encinas R,
Caro-Cuenca T,
Moreno-Montilla M,
Alors-Pérez E,
Keywords:
lung carcinoid,
splicing dysregulation,
splicing events,
splicing machinery,
#3261
Splicing machinery dysregulation in low grade pulmonary carcinoids
Introduction:
Dysregulation of alternative splicing has emerged as a hallmark for cancer. Recently, our group has shown that splicing machinery expression profile is altered in several cancers, including neuroendocrine tumors. In this study, we explored how this machinery is dysregulated in pulmonary carcinoids.
Conference:
18th Annual ENETS Concerence (2021)
Presenting Author:
Blázquez-Encinas R
Authors:
Blázquez-Encinas R,
Caro M,
García-Vioque V,
Pedraza-Arévalo S,
Alors-Pérez E,
Keywords:
neuroendocrine,
carcinoid,
lung,
splicing,
