Abstract Library

#4647 Crosstalk between cancer-associated fibroblasts and small intestinal neuroendocrine tumour cells in a 3D spheroid model

Introduction: At diagnosis, over 50% of small intestinal neuroendocrine tumours (SI-NETs) have metastasised to the mesentery where they often induce extensive fibrosis. Recent studies highlight the crucial interaction between SI-NET cells and cancer-associated fibroblasts (CAFs) in the pathogenesis of mesenteric fibrosis (MF).

Conference:

Presenting Author:

Authors: van der Slik E, Feelders R, van Koetsveld P, Iyer A, Hofland J,

Keywords: mesenteric fibrosis, small intestinal neuroendocrine tumour, CAF,

#4628 Triple negative breast neuroendocrine carcinoma in older patient: A rare entity

Introduction: Neuroendocrine breast carcinoma is a rare histological form of breast cancer, that represent 0.1% of all breast cancers and is recognised by the World Health Organization as a distinct entity. Characterised by a non-specific clinical and radiological presentation. Therapeutic management is not codified and is usually superimposed on that of classical breast cancer.

Conference:

Presenting Author:

Authors: Aris H, Saidi M, Lahfa I,

Keywords: neuroendocrine carcinoma, triple negative breast cancer, platinum-based combination therapy,

#4617 Analysis of new immunohistochemical biomarkers in a cohort of pancreatic NETs

Introduction: Pancreatic neuroendocrine tumours (PanNETs) are rare diseases with a 10-year survival rate of only 40-50%. The ATRX, DAXX and ARX, PDX1 expressions in PanNETs were considered poor prognostic factors in some studies, but inconsistent in others.

Conference:

Presenting Author:

Authors: Ciobanu O, Martin S, Herlea V, Vasilescu F, Balaban D,

Keywords: Pancreatic neuroendocrine tumour, ATRX, DAXX, ARX, PDX1,

#4614 Rare diagnosis of intrapancreatic accessory spleen mimicking PanNET

Introduction: A 44-year-old woman with hypertension and an autoimmune thyroid disease. With a positive family history of pancreatic and oesophageal cancer. Referred to our clinic for an incidental finding of a tumour in the tail of the pancreas on abdominal ultrasound by a surgeon.

Conference:

Presenting Author: Uhrík P

Authors: Uhrík P, Nosakova L, Vojtko M, Bánovčin P,

Keywords: fine needle biopsy, accessory spleen, Neuroendocrine tumour,

#4605 Primary mammary neuroendocrine tumour: A case report and literature review

Introduction: Primary neuroendocrine carcinomas of the breast are rare, accounting for only 2 to 5% of all breast cancers. These tumours have recently been included in the latest WHO classification of breast tumours. The diagnosis can be challenging due to its uncommon presentation and overlap with other breast pathologies.

Conference:

Presenting Author:

Authors: Boudersa A, Kouadri N,

Keywords: primary neuroendocrine, breast cancer,