Abstract Library

#3479 Mesenteric fibrosis in SI-NEN is characterized by strong dysregulation of CXCL9, IL6, COMP and COL6A6 genes

Introduction: Small intestine neuroendocrine neoplasms (SI-NENs) are characterized by the development of desmoplastic mesenteric fibrosis (MF) in up to 50 % of cases. This can cause intestinal obstruction and ischemia, which is a significant clinical problem.

Conference:

Presenting Author:

Authors: Graf S, Keber C, Hattesohl A, Denkert C, Di Fazio P,

Keywords: si-nen, si-net, comp, col6a6, cxcl9, il6, mesenteric fibrosis, desmoplasia, desmoplastic reaction, tumor microenvironment, tme, tumor stroma interaction, next generation sequencing, ngs, htg edgeseq, gene expression analysis, rna,

#3173 Intestinal obstruction (IO) in patients receiving peptide receptor radionuclide therapy (PRRT) for gastro-enteropancreatic neuroendocrine tumors (GEP-NETs): Potential predictors and association with overall survival (OS)

Introduction: There are concerns for the risk of IO in patients with GEPNETs, especially in cases with peritoneal metastases or mesenteric vascular encasement.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Badawy M

Authors: Badawy M, Hobday T, Johnson G, Halfdanarson T, Young J,

Keywords: gastrointestinal NETs, PRRT (Lu-DOTATATE), intestinal obstruction, overall survival,

#2753 Risk of PRRT-Associated Bowel Obstruction in Patients with Mesenteric/Peritoneal Disease and Potential Role of Corticosteroids in Treatment

Introduction: Although radiation-induced mesenteritis or peritonitis can potentially exacerbate risk of bowel obstruction, there are no data in the literature on incidence of intestinal obstruction related to peptide receptor radiotherapy (PRRT)

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Al-Toubah T, El-Haddad G, Pelle E, Strosberg J,

Keywords: PRRT, Lutetium-dotatate, Bowel obstruction, Peritoneal carcinomatosis, Steroids,

#2092 Palliative Surgery in Advanced Small Intestinal Neuroendocrine Tumors

Introduction: Small intestinal neuroendocrine tumours (SI-NETs) are known to develop mesenteric metastasis and fibrosis. Since this can induce intestinal obstruction, edema and ischaemia, prophylactic palliative resection of the primary tumour and mesenteric mass is often recommended in case of advanced disease but the evidence is disputable.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Blazevic A

Authors: Blazevic A, Zandee W, Franssen G, Hofland J, Van Velthuysen M,

Keywords: Small intestinal neuroendocrine tumors, Palliative surgery, Prognosis,

#2061 Midgut Carcinoids Presenting as Subacute Intestinal Obstruction. A Case Report of Territory Care Hospital.

Introduction: Midgut carcinoids are well differentiated neuroendocrine tumors possessing secretary properties releasing various peptides. Over the past few decades, there incidence has been increased. Since countries like Pakistan lack the diagnostic facilities, they are often misdiagnosed.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Fatima A

Authors: Fatima A, Zaidi S,

Keywords: midgut carcinoid, liver metastasis, misdiagnosis, surgery,