Abstract Library

#4546 Epigenetic exploration of mesenteric fibrosis indicates epigenetic disruption of DAXX is driving metastatic potential in small intestinal neuroendocrine tumours

Introduction: Up to 50% of patients diagnosed with small intestinal neuroendocrine tumours (SI-NETs) are affected by mesenteric fibrosis (MF) which has significant pathological effects and impacts patient mortality.

Conference:

Presenting Author: Webster A

Authors: Webster A, Martins M, Hodgetts H, Feelders R, Hofland L,

Keywords: DNA methylation, SI-NET, Mesenteric fibrosis, Epigenetics, Gene regulation, DAXX,

#4235 Tricuspid valve replacement and liver transplantation in a 51-year-old female patient with grade 1 ileum NET and refractory carcinoid syndrome

Introduction: Refractory carcinoid syndrome (RCSy) could lead to severe complications.

Conference:

Presenting Author: Tőke J

Authors: Tőke J, Kövesdi A, Szolnoky J, Huszty G, Piros L,

Keywords: refractory carcinoid syndrome, liver transplantation, ileum neuroendocrine tumor,

#3710 Morphological response on mesenteric mass of small intestinal neuroendocrine tumors treated by 177Lu-DOTATATE: MESENLUTH – A GTE-ENDOCAN study

Introduction: Small intestinal neuroendocrine tumors (SI-NETs) often metastasize, especially to mesenteric lymph nodes, which are frequently affected by fibrosis reactions due to local serotonin secretion. Peptide receptor radionuclide therapy (PRRT) with177Lu-Dotatate has shown its efficacy in the treatment of progressive SI-NETs.

Conference:

Presenting Author: Walter T

Authors: Al Mansour L, de Mestier L, Haissaguerre M, Afchain P, Hadoux J,

Keywords: neuroendocrine tumor, mesenteric mass, objective response, 177Lu-DOTATATE,

#3329 The role of 68Ga-DOTATATE PET/CT in extensive IgG4-positive fibrosis surrounding a mesenteric lymph node metastasis of a neuroendocrine tumor: A case report

Introduction: IgG4 expression is commonly seen in mesenteric tumor deposits from small intestine neuroendocrine tumors leading to a dense fibrotic response which can simulate IgG4-related sclerosing mesenteritis in medical images, hereby impeding a correct diagnosis.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author:

Authors: Ahmadi Bidakhvidi N, Cuyle P, Sagaert X, Ballaux F, De Bruecker Y,

Keywords: small intestine neuroendocrine tumor, 68Ga-DOTATATE PET/CT, mesenterial lymph node, fibrosis, IgG4,

#3099 Evaluating nationwide application of minimally invasive surgery for small bowel neuroendocrine neoplasms and the impact on survival

Introduction: Open surgery for small bowel neuroendocrine neoplasms (SB-NEN) is still considered standard-of-care, mainly because of frequently encountered multifocality and central mesenteric masses.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author:

Authors: Kaçmaz E, Klümpen H, Bemelman W, Nieveen van Dijkum E, Engelsman A,

Keywords: survival, laparoscopy, surgery, small intestine, neuroendocrine neoplasm,