Abstract Library

Welcome to the open-access search for all ENETS abstracts presented at the Annual ENETS Conferences.

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ENETS Abstract Search

#3997 FOXA2-initiated transcriptional activation of INHBA induced by methylmalonic acid promotes pancreatic neuroendocrine neoplasm progression

Introduction: More than 60% of pancreatic neuroendocrine neoplasms (PanNENs) represent metastases when diagnosed. Metabolic alterations have been recognized as one of the hallmarks of tumor metastasis. However, little is known about the molecular mechanism of metabolic changes regulating PanNEN progression.

Conference:

Presenting Author:

Authors: Hu C,

Keywords: metabolic alteration, tumor progression, pancreatic neuroendocrine neoplasm, FOXA2, INHBA, epithelial-mesenchymal transition,

#3767 Metabolic alterations in patients with pheochromocytoma/paragangliomas and SDHB mutations

Introduction: Pheochromocytoma/paragangliomas (PPGL) patients with SDHB mutation may have unfavourable course of disease. SDHB gene inactivation results in up-regulation of glycolytic reaction and activation of pseudo-hypoxic phenotype in preclinical studies.

Conference:

Presenting Author: Benevento E

Authors: Benevento E, Cannavale G, Liccardi A, Minotta R, Modica R,

Keywords: pheochromocytoma, paraganglioma, SDHB,

#3713 Methylmalonic acid activates INHBA induced epithelial-mesenchymal transition and promotes the cancer progression by TGF-β signalling pathway in pancreatic neuroendocrine neoplasm

Introduction: Metabolic reprogramming is a well-recognized hallmark of cancer progression, especially the process of tumor metastasis. However, the role of metabolic alteration and its potential mechanism in pancreatic neuroendocrine neoplasm (pNEN) with metastasis remain elusive.

Conference:

Presenting Author: Hu C

Authors: Hu C, Ye M, Bai J, Tang Q,

Keywords: metabolic reprogramming, pancreatic neuroendocrine neoplasm, methylmalonic acid, INHBA, TGF-β, epithelial-mesenchymal transition,

#320 Predictors of Clinical Response to Everolimus in Patients with Well-differentiated Metastatic Pancreatic NETs

Introduction: Everolimus (E) is an mTOR inhibitor with promising antitumor activity in patients with NETs. Predictor factors of response could improve the clinical use of this compound.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: De Martino M, Ducreux M, Dromain C, Duvillard P, Guigay J, Leboulleux S,

Keywords: everolimus, mTOR, RECIST, pancreas, neuroendocrine, tumor, proliferative index, predictor,