Abstract Library

#4649 Claudin 18.2 overexpression in gastric neuroendocrine tumours

Introduction: Claudin 18.2, is a tissue biomarker physiologically expressed in both healthy gastric mucosa and gastric adenocarcinoma which represents a novel therapeutic target advanced gastric cancer. Various other cancers showed some overexpression of claudin 18.2 opening potential opportunities to agnostic targeted therapy. However, data about claudin 18.2 expression in NENs are poor with only an Eastern study showing higher rate of claudin 18.2 positivity in GEP-NENs, mainly from gastric primary site (27.8%).

Conference:

Presenting Author: Gervaso L

Authors: Gervaso L, Lobrano R, Pisa E, Benini L, Spada F,

Keywords: claudin, gastric NET, biomarker, Neuroendocrine tumour,

#4646 Dysregulated miRNA in patients with GEP-NEN and potential role as circulating biomarker

Introduction: Neuroendocrine neoplasms (NENs) are a class of rare and molecularly extremely heterogeneous tumours. NENs arise predominantly in the gastrointestinal (GEP) and pulmonary tracts but can also involve thyroid and breast. NENs often present with non-specific symptoms and lack early specific biomarkers, leading to frequent metastatic diagnoses and primary site challenges.

Conference:

Presenting Author:

Authors: Di Mauro A, Clemente O, Cannella L, Della Vittoria G, Neri G,

Keywords: neuroendocrine tumour, miRNome profiling, biomarker, gep-net, molecular biology,

#4435 Clinicopathological characteristics and prognosis of 12191 patients with pancreatic neuroendocrine neoplasms

Introduction: Pancreatic neuroendocrine neoplasms (P-NENs) are a group of tumours originating from pancreatic neuroendocrine cells. Although these tumours are relatively rare, studies on them have gradually increased in recent years.

Conference:

Presenting Author:

Authors: Han D, Du H,

Keywords: Pancreatic neuroendocrine neoplasm, Multivariate analysis, Surgery,

#4434 Treatment approaches for gastroenteropancreatic neuroendocrine neoplasms: A twelve-year experience at a single centre in Colombia

Introduction: Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NENs) have multiple treatment options, but their availability varies by cost.

Conference:

Presenting Author: Molina-Pimienta L

Authors: Molina-Pimienta L, Cuellar A, Tapiero-Garcia M, Romero-Rojas A, Sanchez-Castillo J,

Keywords: neuroendocrine tumour, Kaplan-Meier analysis, treatment, Lutetium-177, surgery,

#4419 Real-world outcomes in patients with gastroenteropancreatic neuroendocrine neoplasms at a cancer centre in a middle-income country

Introduction: Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NENs) are rare tumours that are increasing in prevalence. However, the epidemiology of GEP-NENs in Latin America is not well understood.

Conference:

Presenting Author: Molina-Pimienta L

Authors: Molina-Pimienta L, Cuellar A, Tapiero-Garcia M, Romero-Rojas A, Sanchez-Castillo J,

Keywords: neuroendocrine tumour, Kaplan-Meier analysis, middle-income countries, epidemiology,