Abstract Library

#4556 Optimising the establishment of patient-derived models for neuroendocrine neoplasms

Introduction: Neuroendocrine neoplasms (NENs) are clinically and molecularly diverse, with limited understanding of their tumour biology. Efforts to develop patient-derived models have been unsuccessful, highlighting an urgent need for accurate models to support fundamental research.

Conference:

Presenting Author: Hernández Llorens M

Authors: Hernández-Llorens M, Baena-Moreno M, Lamas-Paz A, Sarmentero J, Anton-Pascual B,

Keywords: patient-derived model, organoids, PDXs, Growth factor,

#4183 Establishment of novel patient-derived preclinical models for neuroendocrine tumors

Introduction: Neuroendocrine tumors (NETs) arise in different organs and are heterogeneous with limited treatment options. Preclinical models established from patient tumor specimens enable precision oncology by assessing the response to various drug treatments.

Conference:

Presenting Author: Michael I

Authors: Kulathunga N, Wang Z, Li B, Li Y, Tsui H,

Keywords: preclinical models, patient-derived organoids, patient-derived xenografts, drug screening,

#3931 Construction and comparison of non-functional pancreatic neuroendocrine tumor models

Introduction: Pancreatic neuroendocrine tumors (PNET) which account for more than 80% of pancreatic neuroendocrine neoplasm (pNEN) can be divided into functional and non-functional. The non-functional pancreatic neuroendocrine tumor (NF-pNET) without hormone-related clinical symptoms is frequently found by chance during physical examination or in large primaries and late stages of disease.

Conference:

Presenting Author: Wang Y

Authors: Wang Y, Ye Z, Lou X, Xu J, Zhou C,

Keywords: pancreatic neuroendocrine tumor, preclinical model, cell line, patient-derived organoid, patient-derived xenograft,

#2898 Novel Preclinical Models of Small Bowel Neuroendocrine Tumors for Drug Screening

Introduction: The incidence of neuroendocrine tumors (NETs) from the small bowel (SBNETs) has increased markedly over the past several decades. Many patients with these tumors present with metastatic disease, and research into new treatment options for these tumors have been hindered by the limited number of patient-derived SBNET cell lines and in vivo models available for drug testing.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Ear P

Authors: Ear P, Tran C, Li G, Kaemmer C, Ellen A,

Keywords: SBNET, drug screening, spheroids, PDX models, precision medicine,

#2180 BRAF-V600E Driven Mutations in Grade 3 Neuroendocrine Carcinomas of Colon Origin: Results from Genomic/Epigenomic Profilings and Patient-Derived Mouse Model

Introduction: NECs of colon origin are orphan and highly aggressive neoplasms with limited molecular knowledge.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Capdevila J

Authors: Capdevila J, Mancuso F, Landolfi S, Martinez-Cardus A, Barriuso J,

Keywords: Neuroendocrine carcinoma, Genomics, Epigenomics, BRAFV600E, Patient-derived xenograft,