Abstract Library

#2898 Novel Preclinical Models of Small Bowel Neuroendocrine Tumors for Drug Screening

Introduction: The incidence of neuroendocrine tumors (NETs) from the small bowel (SBNETs) has increased markedly over the past several decades. Many patients with these tumors present with metastatic disease, and research into new treatment options for these tumors have been hindered by the limited number of patient-derived SBNET cell lines and in vivo models available for drug testing.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Ear P

Authors: Ear P, Tran C, Li G, Kaemmer C, Ellen A,

Keywords: SBNET, drug screening, spheroids, PDX models, precision medicine,

#2271 Effects of Multi-Receptor Targeting Drugs in Neuroendocrine Tumors Using 3D Cell Culture

Introduction: Symptom control in functioning neuroendocrine tumors(NETs) may be difficult in some cases, thus, new therapeutic options, including multi-receptor targeting drugs are required.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Herrera-Martínez A

Authors: Herrera-Martínez A, Van Dungen R, Van Koetsveld P, Dogan-Oruc F, Culler M,

Keywords: NETs, somatostatin receptors, dopamine receptors, multi-receptor targeting drugs, hormone secretion,

#2073 Epigenetic Modulation of Autophagy in Pancreatic Spheroid Cells

Introduction: Pancreatic neuroendocrine malignancy is rising up in the last decade. Despite surgical resection and palliative therapy, an effective therapy has not been developed yet.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Matrood S

Authors: Matrood S, Wissniowski T, Wiese D, Gress T, Bartsch D,

Keywords: spheroid, autophagy, pancreatic neuroendocrine tumor, AMPK-alpha, stellate cells,

#1638 3D Primary Cell Culture: A New Promising Preclinical Model for Pancreatic Neuro-Endocrine Tumors (pNETs).

Introduction: The lack of adequate in vitro and in vivo preclinical models has hampered the identification of novel treatment options and the development of personalized therapy selection for pNET patients.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Marinoni I, Mooser C, Wiedmer T, Di Domenico A, Pantasis S,

Keywords: pNET, preclinical models, 3D culture.,

#741 Lanreotide Activity and Synergy in Combination with Targeted Agents in Gastrointestinal Neuroendocrine Tumors (GI-NET): Ex Vivo Analysis of Programmed Cell Death (EVA/PCD) in GI-NETs Isolated from Patients with Advanced Disease

Introduction: Somatostatin receptor ligation can affect vascular signals, induce apoptosis and provide objective responses in some GI-NET patients.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Nagourney R, Evans S, Woltering E, Gomez-Panzani E,

Keywords: combination therapy,