Abstract Library

Welcome to the open-access search for all ENETS abstracts presented at the Annual ENETS Conferences.

Everyone can browse the library to find basic information on abstracts. To get full access to each entry, you will be asked to log in to your myENETS account.

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Participants of the 2025 ENETS Conference enjoy full access to the 2025 conference digital resources through myENETS: the abstract booklet, e-posters and videos, slide decks of talks, the poster carousel, and more.

ENETS Abstract Search

#3966 PTK2 PROTAC unveiled as a selective inhibitor of gastrointestinal neuroendocrine cell proliferation via multi-target drug screening

Introduction: Gastrointestinal neuroendocrine tumors (GI-NETs) exhibit a complex and diverse nature, posing challenges in their effective treatment and management. While there have been advancements in treatment options, addressing the need for more effective and targeted therapies remains a significant issue, especially for patients with advanced or metastatic disease. Improving outcomes in the management of patients with GI-NETs is a key priority, and further research and development are crucial in this regard.

Conference:

Presenting Author: Gagliano T

Authors: Malavasi E, Toffoli L, Dainotto M, Gagliano T,

Keywords: Protac, PTK2, Screening, GI-NETs,

#3469 Hedgehog pathway implications in gastroenteropancreatic neuroendocrine tumors

Introduction: Hedgehog (Hh) signaling pathway has a known role in the development of various tumors and we have selective inhibitors. However, its implications in neuroendocrine tumors (NETs) are still to be unrevealed.

Conference:

Presenting Author:

Authors: Saiz-Lopez P, Alcaraz R, Blanco-Abad C, Garcia-Toro E, Garcia-Girón C,

Keywords: Hedgehog, gastroenteropancreatic, prognostic,

#869 Phase 1 Expansion Study of an Oral TORC1/TORC2 Kinase Inhibitor (CC-223) in Non-Pancreatic Neuroendocrine Tumors (NET)

Introduction: Clinical efficacy of everolimus, an allosteric TORC1-selective inhibitor, has been established in pancreatic NET. CC-223 is an ATP-competitive inhibitor of the mTOR kinase, inhibiting both TORC1 and TORC2.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Meyer T, Mahipal A, Bendell J, Nemunaitis J, Mita M,

Keywords: TORC-1 CC-223,

#265 A Novel PKCßII Inhibitor Induces Antiproliferative Effects in Human Pancreatic Neuroendocrine Tumor Cells

Introduction: Deregulation of the protein kinase C (PKC) signaling pathway has been implicated in tumor progression.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Molè D, Gagliano T, Gentilin E, Bondanelli M, Tagliati F,

Keywords: PKCßII, selective inhibitor, human pancreatic neuroendocrine cell line,