#2905
DNA Methyltransferase Inhibitor Hydralazine Induces Upregulation of Somatostatin Type 2 Receptors in Human Neuroendocrine Tumor Cells
Introduction:
Epidrugs like DNA methyltransferase inhibitors (DNMTi) can increase somatostatin receptor type 2 (SST2) expression in neuroendocrine tumor (NET) cells in vitro and in vivo. This effect could be used for NET patients with low SST2 expression who are currently ineligible for somatostatin analogue (SSA) treatment. However, the DNMTi known to stimulate SST2 have either a high toxicity profile or are not yet approved.
Conference:
17th Annual ENETSConcerence (2020)
Presenting Author:
Refardt J
Authors:
Refardt J,
Klomp I,
van Koetsveld P,
Dogan-Oruç F,
de Herder W,
Keywords:
somatostatin type 2 receptor,
BON-1,
GOT-1,
upregulation,
DNA methyltransferase inhibitor,
histone deacetylase inhibitor,
epigenetic,
#1097
Epigenetic Manipulation of the Somatostatin Receptor Type 2 in Neuroendocrine Tumor Cells
Introduction:
The somatostatin receptor type 2 (sst2) is a target for treatment in patients with neuroendocrine tumors (NET). However, variability in tumoral sst2 expression might lead to variability in response. Epidrugs could increase sst2 levels and improve response to somatostatin analogues (SSA).
Conference:
12th Annual ENETSConcerence (2015)
Presenting Author:
Authors:
Veenstra M,
Van Koetsveld P,
Dogan F,
Farrell W,
Vitale G,
Keywords:
NET,
sst2,
epidrug,
signaling,
#119
Valproic acid induces apoptosis-mediated cell death of the ileal carcinoid cell line GOT1
Introduction:
Downregulation of tumor suppressor genes, evasion from apoptosis, and reduced differentiation are hallmarks of cancer that can be due to abnormal epigenetic control. Histone deacetylase (HDAC) is an enzyme involved in the deacetylation of histone proteins, resulting in chromatin remodelling and altered gene transcription. HDAC inhibitors are emerging as useful anticancer drugs.
Conference:
7th Annual ENETSConcerence (2010)
Presenting Author:
Authors:
Arvidsson Y,
Ahlman H,
Nilsson O,
Keywords:
carcinoid,
HDAC,
apoptosis,
valproic acid,
