Abstract Library

#3386 Peptide Radio Receptor Therapy induces immune activation in patients with neuroendocrine tumors and might sensitize to immunotherapy

Introduction: Peptide Radio Receptor Therapy (PRRT) is a standard treatment in patients with neuroendocrine tumors (NET), but treatment responses are limited and novel therapy combinations are needed. Since radiation induced cell death is considered immunogenic, patients might benefit from a combination of PRRT with immunotherapies, such as immune checkpoint inhibitors (ICI).

Conference:

Presenting Author: Büttner S

Authors: Büttner S, Detjen K, Galler M, Siefert J, Wiedenmann B,

Keywords: NET, PRRT, checkpoint inhibitors, immune response, PD1, flow cytometry,

#3195 Peptide Radio Receptor Therapy sensitizes to immunotherapy by increasing expression of checkpoint molecules in in patients with neuroendocrine tumors

Introduction: Peptide Radio Receptor Therapy (PRRT) represents a standard treatment in patients with well-differentiated neuroendocrine tumors (NET G1/G2). Nevertheless, a lack of response is observed in 1/3 of patients after PRRT, suggesting that combination of PRRT with other therapies might increase its efficacy. The combination of PRRT with immune checkpoint inhibitors (ICI) might be promising, since radiation induced cell death can trigger antigen release and lead to activation of the immune system.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Hammerich L

Authors: Büttne S, Wiedenmann B, Amthauer H, Tacke F, Roderburg C,

Keywords: neuroendocrine tumor, checkpoint blockade, PRRT, immunotherapy, spectral flow cytometry,

#2203 A Case of Rectal Abscess Emerged Immediately after Starting Chemotherapy with Everolimus and Required Surgical Drainage

Introduction: Everolimus is widely used for unresectable panNET. For its efficacy as an immunosuppressant, infectious adverse events are well-known.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author:

Authors: Nakano K, Masui T, Yogo A, Uchida Y, Sato A,

Keywords: everolimus, infection, abscess, rectal abscess, surgery, drainage,

#2163 Peptide Receptor Radionuclide Therapy in Patients with Metastatic Neuroendocrine Carcinomas: Case Series

Introduction: High-grade neuroendocrine carcinomas (NECs) possess inevitable tendencies to metastasise and hold poor prospects of survival. Patients with neuroendocrine tumours who progress after medical management can be treated with peptide receptor radionuclide therapy (PRRT), on the proviso that there is positive uptake on 68Ga-DOTATATE PET/CT imaging. Despite this, a proportion of patients who exhibit positive imaging respond poorly to therapy. Management of NECs is currently limited; evidence for treating NECs with PRRT is scarce.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author:

Authors: Butt S, Evans J, Sharma R,

Keywords: neuroendocrine, carcinoma, tumours, PRRT,

#1457 Small and Large Incidental Non-Hyperfunctiong Pancreatic Neuroendocrine Tumors: Spectrum of Magnetic Resonance Imaging Features

Introduction: The improvement of imaging techniques significantly increased the detection of small incidental non-hyperfunctioning pancreatic neuroendocrine neoplasms (NF-PanNENs). Most NF-PanNENs

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author:

Authors: De Robertis R, D'Onofrio M, Butturini G, Tinazzi Martini P, Paiella S,

Keywords: Pancreas, neuroendocrine neoplasms, magnetic resonance imaging,