Abstract Library

#4185 Primary hepatic neuroendocrine neoplasms – Clinical characteristics and treatment outcomes of a rare disease

Introduction: Liver involvement in Neuroendocrine Neoplasms (NEN) most commonly encompasses metastases from other organs or from an unknown primary. The current WHO classification defines primary hepatic NEN (PHNEN) as a distinct entity. With only few cases of PHNEN reported and difficulty to discern them from hepatic metastases, evidence on optimal management is very limited.

Conference:

Presenting Author:

Authors: Apostolidis L, Kender Z, Flegka V, Winkler E, Krug S,

Keywords: hepatic NEN, liver NEN, PHNEN,

#4119 Interim analysis of LANTana: Phase Ib study investigating up-regulation of somatostatin receptor-2 (SSTR2) with the de-methylating agent ASTX727 to allow [177Lu]Lu-DOTA-TATE in metastatic neuroendocrine tumors (NETs)

Introduction: To be suitable for [177Lu]Lu-DOTA-TATE, SSTR2 must be present on tumor surface as per positive uptake on [68Ga]Ga-DOTA-TATE-PET/CT. SSTR2 promoter methylation reduces SSTR2 expression; this can be reversed using a demethylating agent.

Conference:

Presenting Author:

Authors: Rzeniewicz K, Ward C, Khan S, Naik M, Qurashi M,

Keywords: neuroendocrine tumor, peptide receptor radionucleotide therapy, methylation, [68Ga]Ga-DOTA-peptide-PET, [177Lu]Lu-DOTA-TATE,

#3932 Artisan: Prospective phase II trial of TheraSphere Selective Internal Radiation Therapy (SIRT) for liver metastases in neuroendocrine tumors (NETs)

Introduction: The liver is the commonest site of metastases and is an independent predictor of poor outcome. SIRT allows delivery of high dose radiation to liver metastases and has shown promise in the management of NETs. We determined the safety and efficacy of SIRT in those with inoperable liver metastases in a prospective study.

Conference:

Presenting Author: Ahmed Q

Authors: Ahmed Q, Doumanoglou N, Evans J, Martinez M, Ward C,

Keywords: radioembolization, carcinoid, neuroendocrine, metastases,

#3851 68Ga-DOTATOC PET radiomics as a novel preoperative predictive tool for PanNETs aggressiveness

Introduction: The knowledge of Pancreatic Neuroendocrine Tumors (PanNETs) features of aggressiveness before surgery is fundamental for an appropriate treatment planning.

Conference:

Presenting Author:

Authors: Mapelli P, Bezzi C, Ghezzo S, Muffatti F, Andreasi V,

Keywords: 68Ga-DOTATOC, NET, PET, radiomics,

#3786 Overview of screening and surveillance practices for MEN1-related pancreatic neuroendocrine neoplasms in ENETS CoEs – An ENETS MEN1 Task Force Questionnaire Study

Introduction: The 2012 MEN1 Clinical Practice Guidelines were based on expert opinion with limited evidence, leaving room for interpretation and variation in practices.

Conference:

Presenting Author:

Authors: Pieterman C, Kaltsas G, Valk G, On Behalf of the Enets Men1 Task Force N,

Keywords: men1, screening, surveillance, PanNEN, ENETS CoE, Questionnaire,