Abstract Library

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#4097 Metabolic tumor volume (MTV) as a biomarker in patients with gastroenteropancreatic neuroendocrine neoplasms (GEPNENs): A multicentre study

Introduction: 18F-FDG PET/CT avidity predicts for higher histological grade and worse prognosis in patients with NEN. However, there is less evidence regarding the role of FDG-avid tumor volume in predicting prognosis.

Conference:

Presenting Author:

Authors: Chan D, Hayes A, Karfis I, Conner A, Mileva M,

Keywords: prognostic biomarker, PET imaging, 18F-FDG, metabolic tumor volume,

#3681 18F-FDG PET/CT-avid discordant volume as a biomarker in patients with gastroenteropancreatic neuroendocrine neoplasms – A multicentre study

Introduction: Dual 18F-FDG and 68Ga-DOTATATE PET/CT is emerging as a powerful technique to predict tumor biology. Whilst the presence of discordant disease (FDG avid/DOTA non-avid) predicts poor prognosis, it remains unknown whether the volume of discordant disease is also a significant predictor.

Conference:

Presenting Author: Chan D

Authors: Chan D, Hayes A, Karfis I, Conner A, Mileva M,

Keywords: prognostic biomarker, PET imaging, 18F-FDG, 68Ga-DOTATATE, dual PET, discordance,

#3680 18F-FMISO PET in metastatic neuroendocrine neoplasms – A pilot study

Introduction: The phenomenon of peripheral 68Ga-DOTATATE avidity without central avidity (a so-called “donut") has been observed in neuroendocrine neoplasm (NEN) lesions. There has been speculation as to whether this region of non-avidity reflects hypoxia, de-differentiated disease or other causes. The presence of hypoxia has significant prognostic and therapeutic implications, and was evaluated in these lesions using 18F-FMISO PET/CT.

Conference:

Presenting Author: Chan D

Authors: Chan D, Conner A, Pavlakis N, Bailey E, Aslani A,

Keywords: hypoxia, 18F-FMISO, 68Ga-DOTATATE, PET/CT, biomarker,