Abstract Library

#4656 Development of a 3D patient-derived extracellular matrix hydrogel model of small intestinal neuroendocrine tumour and mesenteric fibrosis

Introduction: The pathogenesis of mesenteric fibrosis in small intestinal neuroendocrine tumours (SI-NETs) is poorly understood, limiting development of effective treatments and biomarkers. A major barrier to research is the lack of disease models.

Conference:

Presenting Author:

Authors: Hodgetts H, Martins M, Luong T, Hall A, Webster A,

Keywords: small intestine, neuroendocrine, 3D model, hydrogel, fibrosis,

#3793 Decellularised pancreas explants as a novel 3D model for pancreatic neuroendocrine tumors (PNETs) biomarker discovery

Introduction: The lack of preclinical models of pancreatic neuroendocrine tumors (pNETs) challenges advancement in biomarker discovery. Culturing cancer cells in their native tissue enables the study of complex tumor cell-ECM interactions, products of which could be utilised as disease biomarkers.

Conference:

Presenting Author: Ney A

Authors: Ney A, Al-Akkad W, Sedlak E, Garcia-Sampedro A, Hall A,

Keywords: Disease model, Tumor microenvironment, Biomarker discovery, Pancreatic NET,

#3450 Re-cellularised human pancreas 3D scaffolds as a novel disease model of pancreatic neuroendocrine tumors (pNETs)

Introduction: A lack of preclinical models of pNETs challenges understanding of complex interactions between cancer cells and their stroma. Traditional in vitro disease models such as 2D cultures however, induce phenotypic and functional drifts consequent of their removal from the native, tissue specific niche. Culturing pNET cells in their native tissue recapitulates specific cell-ECM interactions and tissue remodeling processes.

Conference:

Presenting Author: Ney A

Authors: Ney A, Sedlak E, Garcia-Sampedro A, Hall A, Bhamra A,

Keywords: Disease model, pancreatic neuroendocrine tumor, tissue remodeling, stroma, biomarker,

#3133 Establishment of neuroendocrine neoplasms organoid biobank enables genotype-phenotype mapping

Introduction: Gastroentero-pancreatic (GEP) neuroendocrine neoplasm (NEN) that consists of neuroendocrine tumor (NET) and neuroendocrine carcinoma (NEC) is a lethal but under-investigated disease owing to its rarity. Incidence of this disease is recently increasing, and novel treatment is warranted. However, the establishment and application of GEP-NEN disease models have been limited.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author:

Authors: Kawasaki K, Fujii M, Kudo A, Kanai T, Nakagawa H,

Keywords: organoids, CRISPR-Cas9, multi-omics analysis, gastrinoma, MiNEN,

#2738 Patient-Derived Organoid Models of Human Neuroendocrine Carcinoma

Introduction: Gastroenteropancreatic neuroendocrine carcinoma (GEP-NEC) is a poorly understood disease with limited treatment options. Due to its low incidence and wide tissue distribution few representative preclinical models are available

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Tesselaar M

Authors: Dijkstra K, van den Berg J, Weber F, van de Haar J, Velds A,

Keywords: organoids, gastroenteropancreatic neuroendocrine carcinoma (GEP-NEC), disease modeling, pre-clinical models,