Abstract Library

#4623 [68Ga]Ga-DOTA-Exendin-4 PET/CT for the localisation of insulinoma: Results of an international, dual-centre, retrospective, open-label real-world imaging study

Introduction: Benign insulinomas are the main cause of endogenous hyperinsulinemic hypoglycaemia (EHH) in adults, with surgery as the only cure. Pancreas-preserving procedures are preferred, making precise localisation crucial. Recent studies indicate that GLP-1R imaging, such as [68Ga]Ga-DOTA-exendin-4 (68Ga-Ex4) PET/CT, outperforms conventional imaging in identifying insulinomas.

Conference:

Presenting Author: Fricke J

Authors: Fricke J, Laubner K, Schildmeijer M, Menz L, Christ E,

Keywords: GLP1-Receptor PET/CT, Insulinoma, nesidioblatosis, endogenous hyperinsulinemic hypoglycaemia, real-life data,

#4387 Exenatide-test for diagnosing endogenous hyperinsulinemic hypoglycaemia: A randomised placebo-controlled cross-over proof-of-principle study – FAST study

Introduction: The gold standard to diagnose endogenous hyperinsulinemic hypoglycaemia (EHH) is the fasting test which is cumbersome and incurs high costs. In the setting of radio-labelled 68Ga-exendin-4 PET/CT in patients with EHH (to localise insulinoma), we unexpectedly observed clinically relevant hypoglycaemia following administration of the tracer, which does usually not occur after GLP-1 agonist therapy in type 2 diabetic patients and in healthy subjects.

Conference:

Presenting Author: Christ E

Authors: Hepprich M, Romberg C, Fricke J, Freitag M, Mudry J,

Keywords: endogenous hyperinsulinemic hypoglycaemia, insulinoma, Exendin, Fasting test,

#4327 Metastatic non-functional pancreatic neuroendocrine tumour with transformation to insulinoma shown on 68Ga-Exendin-4 PET/CT

Introduction: 68Ga-exendin-4 PET/CT imaging has been utilised for benign insulinomas. However, some reports demonstrated the absence of GLP-1R expression of malignant insulinomas.

Conference:

Presenting Author:

Authors: Gao J, Xu J, Liang Y, Chen J, Song S,

Keywords: pancreatic neuroendocrine tumour, PET/CT, insulinoma, 68Ga-exendin-4,

#2990 Pitfalls in Glucagon-Like Peptide-1 Receptor Imaging

Introduction: Physiological pancreatico-duodenal DOTA-Exendin-4 uptake in the Brunner’s glands of the proximal duodenum occurs in Glucagon-like peptide-1 receptor (GLP-1R) imaging and is a known potential pitfall.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Antwi K

Authors: Antwi K, Hepprich M, Reubi J, Christ E, Wild D,

Keywords: insulinoma, GLP-1R imaging,

#2003 Comparison of Glucagon-Like-Peptide-1 (GLP-1) Receptor PET/CT, SPECT/CT and 3T MRI for the Localisation of Insulinomas: Evaluation of Accuracy in a Prospective Crossover Imaging Study

Introduction: Benign insulinomas are the most prevalent cause of endogenous hyperinsulinaemic hypoglycaemia (EHH) in adults and due to their small size difficult to localise.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author:

Authors: Antwi A, Heye T, Fani M, Nicolas G, Merkle E,

Keywords: Insulinoma, neuroendocrine tumor, GLP-1R imaging,