Abstract Library

#4476 Pancreatic stellate cells promote tumorigenesis and progression of pancreatic neuroendocrine tumours through SERPINE2 and KCNA5

Introduction: Pancreatic stellate cells (PSC) are stromal cells in the pancreas that play a significant role in pancreatic pathology. Nevertheless, few studies have explored the significance of PSC in pancreatic neuroendocrine tumours (panNET). Their contribution to the fibrotic responses in panNET remains poorly understood. How PSC promote tumorigenesis and differentiation in panNET after being activated to myofibroblasts or cancer-associated fibroblasts (CAF) has not been studied.

Conference:

Presenting Author: Tang Q

Authors: Liu J, Li X, Bai J, Tang Q,

Keywords: caf, stellate cell, pan NET, Oncogenes,

#4350 Cytoendoscopy for determining the depth of invasion and metastasis of rectal neuroendocrine tumours

Introduction: Rectal neuroendocrine tumours (rNETs) are relatively common submucosal tumours, but even low-grade rNETs can metastasise. The significance of endocytology (EC) in the clinical evaluation of rNETs has not been reported.

Conference:

Presenting Author: Tang Q

Authors: Bai J, Tian Y, Tang Q,

Keywords: rectal neuroendocrine tumour, cytoendoscopy, invasion, metastasis, tumour grade,

#3765 Heterogeneity and potential therapeutic targets of rectal neuroendocrine tumors by single cell RNA-sequencing combined with spatial omics

Introduction: The incidence of rectal neuroendocrine tumors (rNETs) has increased rapidly in the past 30 years. However, the molecular mechanism of its occurrence and development is still unclear, and the basic research is relatively backward.

Conference:

Presenting Author:

Authors: Bai J, Tang Q,

Keywords: neuroendocrine tumor, single cell RNA sequencing, spatial transcriptome, heterogeneity, tumor microenvironment, phospholipase d3, metastasis,

#3079 Novel Symptoms and Therapy of Multiple Endocrine Neoplasia Type 1

Introduction: MEN1 is a rare autosomal inherited disease with hallmark of hyperparathyroidism, duodenopancreatic NENs and pituitary tumor.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: bai J

Authors: Bai J, Tang Q,

Keywords: MEN1, LGCS, NENs, gastrinoma, Parathyroid carcinoma,

#2881 Patient-Derived Tumor Xenograft Combined with Chemotherapy Drug Sensitivity Test in a Patient with Pancreatic Neuroendocrine Carcinoma

Introduction: Pancreatic neuroendocrine carcinoma (p-NEC) with liver metastasis has a poor prognosis. The treatment is mainly chemotherapy which is now still a huge challenge on NEC with high ki-67 index.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Bai J

Authors: Bai J, Tang Q,

Keywords: Pancreatic neuroendocrine carcinoma, chemotherapy, Doxorubicin+mitomycin+loplatin, patient-derived tumor xenograft, Carbon ion,