Abstract Library

#4607 BH3-mimetic drugs elicit cell death of neuroendocrine tumours in preclinical models – An emerging therapeutic strategy for NETs

Introduction: There is an unmet clinical need to identify new, effective therapies for patients with neuroendocrine tumours (NETs). Analysis of single-cell expression data revealed that NETs express high levels of the Bcl2 family of antiapoptotic proteins. Therefore, we hypothesised that proapoptotic drugs, such as BH3-mimetics, can induce programmed cell death, i.e., apoptosis, of neuroendocrine cancer cells.

Conference:

Presenting Author: Michael I

Authors: Kulathunga N, Wang Z, Kale J, Lens A, Tsui H,

Keywords: neuroendocrine tumour, BH3-mimetics, Navitoclax, Cabozantinib, patient-derived organoids, apoptosis, 177Lu-Dotatate,

#4254 Leak rates in pancreatico-duodenectomy procedures in pancreatic NETs compared to pancreatic ductal adenocarcinoma resections

Introduction: Pancreatic resection for Neuroendocrine tumor is associated with a higher risk of anastomotic leak and post-operative pancreatic fistula (POPF).

Conference:

Presenting Author: Kalepu J

Authors: Kalepu J, Sundaravadanan S, Pike T, Karavias D, Hamady Z,

Keywords: Pancreatic resection, Whipple, pancreatic fistula, drain amylase,

#3843 VIPoma presenting as chronic diarrhea in a 30-year-old Filipino female

Introduction: Pancreatic neuroendocrine tumors are rare neoplasms that arise in the endocrine tissues of the pancreas. They can secrete a variety of peptide hormones including insulin, gastrin, glucagon, and vasoactive intestinal peptide. Secretory tumors such as vasoactive intestinal polypeptides are rare neuroendocrine pancreatic neoplasms characterized by watery diarrhea, hypokalemia, and hypochlorhydria.

Conference:

Presenting Author: Edejer P

Authors: Edejer P, Mendoza R, Pascasio C, Lin T, Cornelio G,

Keywords: Pancreatic NET, Octreotide, DOTATATE, diarrhea,

#3556 Radioembolization of neuroendocrine neoplasms liver metastases: Efficacy and toxicity

Introduction: In patients with unresectable liver metastases, radioembolization has been used to treat tumors from a range of cancers, including neuroendocrine neoplasms.

Conference:

Presenting Author:

Authors: Gola M, Syguła A, Szynkiewicz J, Olczyk T, Kalemba M,

Keywords: radioemolisation liver metastasis,

#3378 Clinical impact of 68 GA DOTANOC PET CT and 18 F FDG PET CT in clinical management of WHO Grade 2 neuroendocrine tumors

Introduction: WHO well differentiated grade 2 NET is large subgroup with extensive tumor heterogeneity. Both FDG and DOTA PET CT are influential in the management of NET. We determine the clinical impact of dual tracer imaging in grade 2 NET.

Conference:

Presenting Author:

Authors: Kale S, Puranik A, Purandare N, Shah S, Agrawal A,

Keywords: grade 2 NET, DOTA, FDG, Mib index,