Abstract Library

#4609 External validation of Rachel score: A prognostic tool for lung neuroendocrine tumours

Introduction: Lung NETs are a heterogeneous group of tumours with variegated clinical presentation and course. The histological subtype (TC vs AC) and TNM stage are established prognostic factors. In a previous work by our group, we developed a prognostic model named Rachel score, with a satisfactory ability to predict OS and PFS in this population.

Conference:

Presenting Author: La Salvia A

Authors: La Salvia A, Marcozzi B, Lamberti G, Manai C, Mazzilli R,

Keywords: lung neuroendocrine tumour, prognostic tool, Rachel score, external cohort, validation,

#4219 MAPK and mTOR pathway activation is associated with chemotherapy resistance and a poor prognosis in G3 advanced NENs

Introduction: Neuroendocrine neoplasms (NENs) comprise a broad spectrum of disease ranging from slowly progressive to highly aggressive carcinomas.

Conference:

Presenting Author: Catoya J

Authors: Catoya J, Anton-Pascual B, Farinea G, Modrego A, La Salvia A,

Keywords: NEN, mTOR/MAPK pathway, molecular profiling, platinum-based,

#4205 Precision medicine in advanced NENs: Molecular profiling and target actionability real world data

Introduction: Molecular profiling (MP) of NENs is not performed on routine basis and its potential clinical use is a matter of debate.

Conference:

Presenting Author: Farinea G

Authors: Farinea G, Anton-Pascual B, Catoya J, Modrego A, La Salvia A,

Keywords: Genomic Profiling, ESCAT, NEN, Precision Medicine,

#4086 Prognostic significance of metabolomics clusters in extra-pancreatic NETs: Lung NET sub-analysis

Introduction: Metabolic flexibility is one of the key hallmarks of cancer and metabolites are the final products of this adaptation, reflecting the aberrant changes that support cancer cells proliferation and survival. In a previous metabolomics study carried out by our group, multiplatform untargeted metabolomic profiling (GC-MS, CE-MS and LC-MS) performed on plasma samples from 77 advanced G1-2 extra-pancreatic NET patients demonstrated that these patients have a distinct metabolomic profile, and identified methionine, porphyrin and tryptophan metabolism as the most relevant dysregulated pathways associated with the prognosis of NETs. Furthermore, a 3-metabolite signature was able to stratify patients in 3 distinct prognostic clusters, with cluster 3 associated with the best prognosis.

Conference:

Presenting Author:

Authors: La Salvia A, Lens-Pardo A, Carretero-Puche C, Capdevila J, Benavent M,

Keywords: metabolimics, prognostic biomarker, lung neuroendocrine tumor, metabolomic signature,

#3930 Gender role in the authorship of Italian academic medical literature on neuroendocrine neoplasms: Cliché or reality?

Introduction: There is an increasing attention to gender equality in the medical setting. While males have dominated the physician lines over the last decades the recent female doctors’ number increasing might reduce this gender gap. However, this may be not true in the academic area.

Conference:

Presenting Author: Rossi R

Authors: Rossi R, La Salvia A, Modica R, Spada F,

Keywords: gender gap, gender equality, neuroendocrine literature, academic setting,