Abstract Library

#4158 Transcriptomic analysis of PanNET tumor progression from microtumor to metastasis in MEN1 patients

Introduction: Pancreatic Neuroendocrine Neoplasms (PanNENs) are a major component the Multiple Endocrine Neoplasia 1 Syndrome (MEN1). Although multiple pancreatic neuroendocrine microtumors (microadenomatosis) are a histomorphological hallmark of MEN1, their molecular status compared to PanNET as well as their metastasis remains unclear.

Conference:

Presenting Author:

Authors: Chouchane A, Kirchner P, Sylvain Maire R, Schiavo Lena M, Falconi M,

Keywords: Microtumor, MEN1, PanNETs, RNAseq, Transcriptomics, Progression,

#3824 A rare clinical case of giant pituitary ACTH adenoma

Introduction: Cushing's disease is a neuroendocrine disease that is associated with ACTH-secreting pituitary microadenomas whereas macro- and giant adenomas are less common.

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Presenting Author:

Authors: Lastovkina A, Ilovaiskaya I, Komerdus I, Motrenko A, Zakharova P,

Keywords: Cushing's disease, giant corticotropinoma, hypercortisolism,

#3542 Essential role of nutritional support in patients with advanced carcinoid heart disease

Introduction: Chronic heart failure leads to cachexia in 5-15% of patients. Malnutrition affects 58% of patients with carcinoid syndrome.

Conference:

Presenting Author:

Authors: Shah H, Mair R, Arif S, Smith S, Vickrage S,

Keywords: carcinoid syndrome, carcinoid heart disease, nutrition, nasogastric feeding,

#3388 Epigenetic progression steps in alpha-lineage MEN1-DAXX/ATRX mutated Pancreatic Neuroendocrine Tumors (PanNET)

Introduction: Recently, based on DNA methylation profiles, we have hypothesized that PanNETs with mutations in ATRX, DAXX and MEN1 originate from α-cells. Alpha-like PanNETs, small and indolent, were enriched for mutations in MEN1 only, while epigenetically intermediate PanNETs, larger and with high relapse risk, showed mutations in both MEN1 and DAXX/ATRX (Int-ADM). Int-ADM PanNETs show progressive loss of alpha cell differentiation.

Conference:

Presenting Author: Marinoni I

Authors: Di Domenico A, Kirchner P, Maire R, Thirlwell C, Perren A,

Keywords: Epigenetics, DAXX/ATRX, PanNET, PanNET progression,

#3379 Survey of neuroendocrine tumor patients’ experience of quality of care provided by a dedicated NET Dietitian

Introduction: The Birmingham Neuroendocrine Tumour (NET) service has a full time dedicated NET Dietitian for outpatient and inpatient care since August 2020.

Conference:

Presenting Author: Mair R

Authors: Mair R, Bradley E, Davis N, Shah T,

Keywords: net, DIETITIAN, QUALITY OF LIFE, SYMPTOM CONTROL,