Abstract Library

#4608 A complex and rare association of neuroendocrine and endocrine neoplasms: A case report

Introduction: Neuroendocrine tumours (NETs) are sporadic or genetically inherited heterogenous neoplasms affecting multiple sites.

Conference:

Presenting Author: Cerroni L

Authors: Cerroni L, Filice A, Feola T, Sesti F, Vincenzi L,

Keywords: cushing disease, atypical carcinoid, ileal net, genetics,

#4565 Evaluation of duodenal neuroendocrine tumours according to MCSC register

Introduction: Neuroendocrine tumours (NETs) of the duodenum are relatively rare tumours and account for 4% of all gastroenteropancreatic NETs.

Conference:

Presenting Author:

Authors: Petrova A, Salimgereeva D, Feidorov I, Konyakhina A,

Keywords: duodenal, register, atrophic gastritis, NET, grade, papilla,

#4519 ANXA1-labelled cancer-associated fibroblasts induces tumour invasion and immunosuppressive microenvironment

Introduction: The growth pattern of a tumour is a marker for distinguishing inert from invasive tumours. In general, tumours such as the encapsulated follicular variant of papillary thyroid carcinoma show expansive growth. In contrast, invasive tumours, such as colorectal cancer and squamous cell carcinoma of the tongue, show invasive growth with infiltration into surrounding structures and have a poorer prognosis. Pancreatic neuroendocrine neoplasm (PNEN) is the heterogeneous tumour originating from peptidergic neurons and neuroendocrine cells. PNEN with a high proportion of tumour mesenchyme, especially those presenting an infiltrating stroma, have a poor prognosis. In the infiltrating mesenchyme, cancer-associated fibroblasts (CAF) play an important role. However, little research has been done on the mechanisms of how infiltrating CAF affects tumour malignancy and immune microenvironment.

Conference:

Presenting Author: Wang Y

Authors: Wang Y, Xu J, Chen J, Xu X, Ji S,

Keywords: pancreatic neuroendocrine neoplasm, tumour-associated fibroblasts, immunosuppressive microenvironment,

#4425 Ampullary composite gangliocytoma/neuroma and neuroendocrine tumour management

Introduction: Ampullary composite gangliocytoma/neuroma and neuroendocrine tumour (CoGNET), previously called ampullary gangliocytic paragangliomas (GP) are a rare entity, with only few reported cases in the literature.

Conference:

Presenting Author: Karam E

Authors: Karam E, Hollenbach M, Heise C, Abou Ali E, Gulla A,

Keywords: ampulla of Vater, gangliocytic paraganglioma, pancreaticoduodenectomy, transduodenal surgical ampullectomy, endoscopic papillectomy, composite gangliocytoma/neuroma neuroendocrine tumour, CoGNET,

#4240 Plasma extracellular vesicles number and size distinguish patients with neuroendocrine neoplasms

Introduction: Neuroendocrine Neoplasms (NENs) are heterogeneous neoplasms, whose metastatic potential is challenging to predict. Extracellular vesicles (EVs) have been described as mediators of communication between the tumor cells and their microenvironment, driving the formation of metastatic niches.

Conference:

Presenting Author: Angelioudaki I

Authors: Angelioudaki I, Pantazatou V, Tzingounis A, Kataki A, Memos N,

Keywords: Extracellular vesicles, plasma, Gastroenteropancreatic NEN,