Abstract Library

#4646 Dysregulated miRNA in patients with GEP-NEN and potential role as circulating biomarker

Introduction: Neuroendocrine neoplasms (NENs) are a class of rare and molecularly extremely heterogeneous tumours. NENs arise predominantly in the gastrointestinal (GEP) and pulmonary tracts but can also involve thyroid and breast. NENs often present with non-specific symptoms and lack early specific biomarkers, leading to frequent metastatic diagnoses and primary site challenges.

Conference:

Presenting Author:

Authors: Di Mauro A, Clemente O, Cannella L, Della Vittoria G, Neri G,

Keywords: neuroendocrine tumour, miRNome profiling, biomarker, gep-net, molecular biology,

#4244 Cell-free DNA (cfDNA) methylation profiling for minimally invasive cancer detection in patients with Extra-Pulmonary NeuroEndocrine Carcinoma (EP-NEC)

Introduction: Robust biomarkers to aid clinical management of patients (pts) with EP-NEC are lacking. cfDNA methylation profiling has shown higher sensitivity/specificity than cfDNA genome profiling in diagnosing and classifying various cancers, including Small Cell Lung Cancer (SCLC).

Conference:

Presenting Author: Frizziero M

Authors: Frizziero M, Pearce S, Clipson A, Rothwe D, Mouliere F,

Keywords: Extra-Pulmonary NeuroEndocrine Carcinoma, cfDNA, methylation profililing, biomarker,

#3301 Telotristat in the management of carcinoid diarrhoea - Real world experience of patients from an ENETS Centre of Excellence in neuroendocrine tumors

Introduction: Carcinoid syndrome occurs in 20% patients, presenting with flushing, abdominal pain, diarrhoea, and wheeze. The standard of care for carcinoid syndrome is somatostatin analogues (SSAs) with add-on Creon, codeine and loperamide therapy. Nonetheless, half of patients experience debilitating diarrhoea. Telotristat-ethyl is a peripheral tryptophan-hydroxylase inhibitor approved for treatment of diarrhoea, supported by Phase-3 clinical trials.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Cianci N

Authors: Khanna A, Cianci N, Shah H, Chauhan J, Pipe M,

Keywords: Telotristat, carcinoid syndrome, somatostatin analogues, neuroendocrine tumor,

#2281 A Novel Classification of Pancreatic Neuroendocrine Tumors (pNETs) Guided by Genomics

Introduction: NET outcomes differ by primary site. Yet pNETs are classified using a generic GI grading system.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Lawrence B

Authors: Lawrence B, Blenkiron C, Parker K, Yeong M, Kramer N,

Keywords: pancreatic NET, genomics,

#440 The First Neuroendocrine Tumor Methylome Using Methylation-Specific Immunoprecipitation Followed by Second Generation Sequencing – MeDIP-seq

Introduction: Recently, the first cancer methylomes have been created which identified differential methylation at CpG island-shores (2kb upstream of CpG islands) to be of particular importance in the tumourigenic process.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Thirlwell C, Sasmaz S, Dibra H, Feber A, Butcher L,

Keywords: DNA methylation, neuroendocrine ,