Abstract Library

#3989 Hypoxia upregulating ACSS2 enhances lipid metabolism reprogramming through HMGCS1 mediated PI3K/AKT/mTOR pathway to promote the progression of pancreatic neuroendocrine neoplasms

Introduction: Pancreatic neuroendocrine neoplasms (pNENs) are relatively rare. Hypoxia and lipid metabolism-related gene acetyl-CoA synthetase 2 (ACSS2) is involved in tumor progression, but its role in pNENs is not revealed.

Conference:

Presenting Author:

Authors: Gu D, Ye M, Zhu G, Bai J, Tang Q,

Keywords: hypoxia, ACSS2, lipid metabolism reprogramming, HMGCS1, PI3K/AKT/mTOR pathway, pancreatic neuroendocrine neoplasm,

#3504 Telotristat ethyl affects crosstalk between tumor cells and stromal fibroblasts in small intestinal neuroendocrine tumors (SI-NETs)

Introduction: SI-NETs are often associated with mesenteric fibrosis (MF) which causes significant morbidity and mortality. Telotristat ethyl (TE) was developed to treat carcinoid syndrome in SI-NET patients however, recent studies indicated TE could also have anti-tumor activity, the mechanism for which remains unclear.

Conference:

Presenting Author:

Authors: Hodgetts H, Martins M, Chen L, Laskaratos F, Hall A,

Keywords: fibrosis, fibroblast, crosstalk, telotristat, intestine, small, tumor,

#3469 Hedgehog pathway implications in gastroenteropancreatic neuroendocrine tumors

Introduction: Hedgehog (Hh) signaling pathway has a known role in the development of various tumors and we have selective inhibitors. However, its implications in neuroendocrine tumors (NETs) are still to be unrevealed.

Conference:

Presenting Author:

Authors: Saiz-Lopez P, Alcaraz R, Blanco-Abad C, Garcia-Toro E, Garcia-Girón C,

Keywords: Hedgehog, gastroenteropancreatic, prognostic,

#3463 Jagged 1 restrains malignant progression in pancreatic neuroendocrine neoplasia

Introduction: Notch pathway is a pivotal regulator of pancreatic organogenesis and postnatal maintenance, yet its role in pancreatic neuroendocrine neoplasias (pNENs) remains ill-defined.

Conference:

Presenting Author:

Authors: Paramonov V, Mamaeva V, Laiho I, Kronqvist P, Vázquez-Ulloa E,

Keywords: pancreatic neuroendocrine tumor/neoplasia, Notch pathway, Jagged 1,

#3251 Impact of Wnt signalling on CXCR4 expression and function

Introduction: Loss of Somatostatin Receptor 2 (SSTR2) expression and rising Chemokine Receptor Type 4 (CXCR4) expression are associated with increasing dedifferentiation in Neuroendocrine Tumors (NET). CXCR4 expression is associated with enhanced metastatic and invasive potential and worse prognosis in NET, but might be a theranostic target in NET not sufficiently expressing SSTR2. Likewise, aberrant activation of Wnt/β-catenin signalling may promote a more aggressive phenotype in NET.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Weich A

Authors: Weich A, Rogoll D, Mayer L, Meining A, Kudlich T,

Keywords: neuroendocrine, NET, CXCR4, Wnt, Wnt Signalling, beta-catenin, BON-1, QGP-1,