Abstract Library

#4468 Prevalence of familial pheochromocytoma and paraganglioma syndromes – A large multicentre study

Introduction: Pheochromocytoma and paraganglioma (PPGLs) are rare tumours. Depending on the studied population, approximately 30% of PPGLs are caused by a germline pathogenic variant (PV).

Conference:

Presenting Author: Halperin R

Authors: Halperin R, Reznick-Levi G, Khalaileh A, Svirsky-Frayden R, Reish O,

Keywords: paraganglioma, pheochromocytoma, genetic evaluation, catecholamine, sdhb, vhl,

#4090 Octreotide infusion pump in patients with functional neuroendocrine tumors and refractory hormonal syndromes

Introduction: In patients with metastatic functional neuroendocrine tumors (NETs), symptoms are, sometimes, not adequately controlled with long-acting somatostatin analogues (LASSAs), so patients need to use boost subcutaneous (sc) octreotide injections (inj) daily. However, this approach is not always effective and convenient for the patients.

Conference:

Presenting Author: Thuringer J

Authors: Thuringer J, Parker G, Sarma A, Hayes A, Mandair D,

Keywords: carcinoid syndrome, VIPoma, Octreotide, pump, refractory, subcutaneous,

#3843 VIPoma presenting as chronic diarrhea in a 30-year-old Filipino female

Introduction: Pancreatic neuroendocrine tumors are rare neoplasms that arise in the endocrine tissues of the pancreas. They can secrete a variety of peptide hormones including insulin, gastrin, glucagon, and vasoactive intestinal peptide. Secretory tumors such as vasoactive intestinal polypeptides are rare neuroendocrine pancreatic neoplasms characterized by watery diarrhea, hypokalemia, and hypochlorhydria.

Conference:

Presenting Author: Edejer P

Authors: Edejer P, Mendoza R, Pascasio C, Lin T, Cornelio G,

Keywords: Pancreatic NET, Octreotide, DOTATATE, diarrhea,

#3567 Metastatic mixed VIPoma/PPoma-induced diarrhoea causing renal failure

Introduction: Pancreatic neuroendocrine tumors (pNETs) are rare, but despite better prognosis than other pancreatic tumors, their presentation is often occult. VIPomas are a further subtype secreting vasoactive intestinal peptide (VIP). Associated symptoms are particularly non-specific, with watery diarrhoea and electrolyte disturbance which mimics less sinister pathology. Consequently, this presentation is often overlooked resulting in tumor progression and delayed diagnosis, hindering effective management.

Conference:

Presenting Author: Monaghan A

Authors: Monaghan A, Brown G, Takhar A,

Keywords: Pancreatic Neuroendocrine Tumor, Neuroendocrine Tumor, pNET, Vasoactive Intestinal Peptide, VIPoma, Pancreatic Polypeptide,

#3271 Comprehensive metabolomic plasma profiling identifies novel potential diagnostic biomarkers in patients with advanced neuroendocrine tumors

Introduction: NETs are heterogeneous neoplasms that have the capacity to secrete hormones or bioactive molecules. Dysregulated metabolism is one of the key hallmarks of cancer and the altered expression of metabolic enzymes is deeply involved in tumor development, progression, and metastasis.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author:

Authors: Soldevilla B, Lens-Pardo A, López-López �, Carretero-Puche C, La Salvia A,

Keywords: NETs, metabolic signalling, plasma metabolites, diagnostic biomarker,