#4174
Uncovering the genomic profiling of metastatic pheochromocytomas and paragangliomas: Leveraging plasma circulating tumor DNA for comprehensive genetic characterisation and monitoring
Introduction:
Liquid biopsy, notably plasma circulating tumor DNA (ctDNA), is a non-invasive approach to elucidate the tumoral genomic profile from a blood sample. Pheochromocytomas and paragangliomas (PPGL) are often operated, characterized by quiet genomes and usually indolent tumor growth. However, challenges arise with metastatic tumors due to accessibility, catecholamine-related crises and surgery issues. Thus, molecular mechanisms transitioning from indolent to metastatic tumors are largely unexplored.
Conference:
Presenting Author:
Authors:
Arenillas Lallana C,
Moreno-Cárdenas A,
Casteràs A,
García-Álvarez A,
Hernando J,
Keywords:
liquid biopsy,
ctDNA,
metastasis,
pheochromocytoma,
paraganglioma,
genomic targets,
#4073
Comparative targeted NGS analysis between solid and liquid biopsies in GEP-NET: A pilot study
Introduction:
Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) present a broad clinical variability. Genetic profile could be a striking resource to respond to prognostic and treatment purposes. Sequencing of circulating tumor DNA (ctDNA) from liquid biopsy (LB) has been proposed as a less invasive alternative to solid biopsy (SB).
Conference:
Presenting Author:
Authors:
Gagliardi I,
Borges de Souza P,
Martiradonna M,
Rossi L,
Albertelli M,
Keywords:
Genetic profile,
Liquid biopsy,
Solid biopsy,
GEP-NET,
ctDNA,
#3422
Longitudinal copy number alteration analysis in plasma cell-free DNA of neuroendocrine neoplasms is a novel specific biomarker for diagnosis, prognosis and follow-up
Introduction:
Research on liquid biopsies in neuroendocrine neoplasms (NENs) remains limited, despite the urgent need for new, preferably blood-based, biomarkers. Copy number alterations (CNAs) represent an important type of molecular alteration in NENs and are detectable in cell-free DNA (cfDNA).
Conference:
Presenting Author:
Authors:
Mariën L,
Boons G,
Vandamme T,
Lybaert W,
Roeyen G,
Keywords:
neuroendocrine neoplasm,
liquid biopsies,
circulating tumor DNA,
biomarker,
copy number alterations,
