Abstract Library

#4583 Improved assessment of gene rearrangements by targeting non-coding DNA regions in patients diagnosed with pancreatic neuroendocrine neoplasms

Introduction: Whole-genome sequencing projects documented the heterogeneity of pancreatic neuroendocrine neoplasms (PanNEN), while showing that few core pathways are consistently affected in their tumorigenesis. Comprehensive genomic profiling (CGP) of real-world cases is expected to recapitulate such heterogeneity for patient stratification and to inform precision therapy. While coding DNA is the focus of current CGP panels, the potential of targeting non-coding DNA (ncDNA) to improve structural variants detection has not been widely explored in this context.

Conference:

Presenting Author: Agnoletto C

Authors: Agnoletto C, Trevisani E, Borghesani M, Landoni L, Luchini C,

Keywords: neuroendocrine, non-coding DNAs, structural variants, clinical relevance, CGP panel,

#4557 miR-1290 and miR-320c regulate cell proliferation and predict patient prognosis in neuroendocrine carcinomas

Introduction: The biology of neuroendocrine carcinomas (NECs) remains largely unknown, limiting the use of biomarkers for patient stratification and therapy response prediction in clinical practice.

Conference:

Presenting Author: Liverani C

Authors: Liverani C, Sgolacchia F, Bongiovanni A, Calabrese C, Vanni S,

Keywords: biomarker, miRNAs, neuroendocrine carcinoma,

#4070 Ordinary colorectal cancers expressing synaptophysin: Myth or reality?

Introduction: Despite the neuroendocrine differentiation in CRCs has been extensively assessed, currently there are no established criteria for inclusion for this designation.

Conference:

Presenting Author:

Authors: Sabella G,

Keywords: neuroendocrine, MANEC, synapthophysin,

#3854 Protein validation of multi-omic classified pulmonary carcinoid – Identification of unique clinical subtypes and potential therapeutic vulnerability

Introduction: Multi-omic studies have identified three pulmonary carcinoid (PC) subtypes (A1, A2, B) with unique expression for OTP, ASCL1 & HNF1a.

Conference:

Presenting Author: Derks J

Authors: Derks J, Moonen L, Leunissen D, von der Thüsen J, den Bakker M,

Keywords: lung carcinoid, biomarker, molecular profile, OTP, ASCL1, HNF1a,

#3811 Multi-omic factor analysis (MOFA) of well-differentiated neuroendocrine tumors (NETs) from different tumor sites

Introduction: NENs are a heterogeneous family of tumors of wide anatomical distribution that share common clinical and biological traits. Although some studies have characterized the molecular landscape of specific primary locations, there is no cross-site molecular classification of NENs.

Conference:

Presenting Author: Carretero C

Authors: Carretero C, Antón-Pascual B, Lens-Pardo A, Benavent M, Gómez-Izquierdo L,

Keywords: NET, MOFA, multi-omics, clinical features, survival,