Abstract Library

#3952 Peptide Receptor Radionuclide Therapy (PRRT) in the management of patients with ectopic Cushing’s syndrome due to metastatic gastroenteropancreatic neuroendocrine neoplasia (GEPNEN): A single centre experience

Introduction: Metastatic GEPNEN can cause ectopic Cushing’s syndrome (ECS). ECS is highly morbid and often refractory to medical therapy. Bilateral adrenalectomy (BA) carries risk and long-term morbidity. Patients (pts) unsuitable for surgery have dismal outcomes. Peptide receptor radionuclide therapy (PRRT) is a rational option for hormone control in ECS caused by NEN with high somatostatin receptor (SSTR) expression yet detailed case series to guide its use are lacking.

Conference:

Presenting Author: Boehm E

Authors: Boehm E, Hung T, Akhurst T, Alipour R, Cardin A,

Keywords: GEPNEN, PRRT, Ectopic Cushing's Syndrome,

#3764 Therapeutic response of ACTH-dependent ectopic Cushing's syndrome to low doses of osilodrostat

Introduction: Cushing's disease (CD) is the main cause of ACTH-dependent Cushing's syndrome (ACTH-CS). In 5–15% of cases, ACTH/CRH production is ectopic and is caused by neuroendocrine tumors of the lung, thymus, or pancreas, medullary thyroid carcinoma, and pheochromocytoma. Diagnostic imaging can locate the primary tumor; however, between 8-22% the cause is unknown. The FDA approved Osilodrostat for the treatment of inoperable or refractory CD, its use in high doses in patients with ectopic CS has been reported.

Conference:

Presenting Author:

Authors: González Devia D, Florez-Romero A, Rojas-Camacho J, Herrera Almario G, Jimenez Hakim E,

Keywords: ACTH-dependent Cushing's syndrome, Osilodrostat, Adrenal steroidogenesis inhibitors, Ectopic ACTH Cushing´s syndrome,

#3728 ACTH-secreting pancreatic neuroendocrine neoplasms – A case-series

Introduction: Ectopic Cushing’s syndrome occurs rarely in patients with pancreatic neuroendocrine neoplasms. Early recognition of symptoms is critical given the high morbidity and mortality associated with Cushing’s syndrome.

Conference:

Presenting Author: Al-Toubah T

Authors: Al-Toubah T, Pelle E, Hallanger-Johnson J, Haider M, Strosberg J,

Keywords: pancreatic neuroendocrine neoplasm, Cushing’s syndrome, ACTH, ectopic Cushing’s, neuroendocrine tumor,

#3679 Ectopic Cushing's syndrome caused by a well differentiated ACTH-secreting neuroendocrine tumor of the ileum

Introduction: Ectopic Cushing syndrome is responsible for 20% of cases of Cushing’s syndrome (CS); with presentation ranging from undetectable lesions to metastatic carcinomas. Ectopic ACTH syndrome (EAS) of intestinal origin is very rare, only five patients have been reported. In this article, we report a case of an ileal ACTH-secreting Neuroendocrine tumor.

Conference:

Presenting Author:

Authors: González Devia D, Llanos-Orozco N, López-Mesa de Mesa J, Fierro-Maya L, Cuéllar-Cuéllar A,

Keywords: Ectopic ACTH syndrome, Midgut Neuroendocrine Tumor, Ectopic Cushing syndrome, Neuroendocrine Tumor, Small intestine tumor,

#3454 Thymic neuroendocrine tumors: Case series from a Colombian hospital reference

Introduction: Thymic neuroendocrine tumors (tNET) are extremely rare, with a wide range of clinical manifestations, which can lead to underdiagnosis. Specific therapies have not been evaluated to improve survival.

Conference:

Presenting Author:

Authors: González Devia D, Fernández Mantilla D, Pino Villareal L, Segovia Gómez J, Urrego Meléndez O,

Keywords: Thymic Neuroendocrine Carcinoma, Thymic Neuroendocrine Tumor, Neuroendocrine Carcinoma, Cushing's Syndrome, Thymus,