#4319
Everolimus combined with orlistat inhibits the development of neuroendocrine tumours by inhibiting the mTOR-PI3K-Akt signalling pathway
Introduction:
Everolimus, an mTOR inhibitor, has demonstrated efficacy in NET treatment. Orlistat, used primarily for obesity management, inhibits fat absorption. This study investigates the potential synergistic effects of Everolimus combined with Orlistat on the development of NETs.
Conference:
Presenting Author:
Authors:
Xu L,
Tang Q,
Ye M,
Keywords:
Everolimus,
orlistat,
mTOR,
PI3K/Akt,
signalling pathway,
#962
Cyclin D1 Levels are Involved in the Resistance to m-TOR Inhibitors in Human Bronchial Carcinoids
Introduction:
Bronchial carcinoids (BC) are still orphans of medical therapy. We previously demonstrated that the typical BC human cell line NCI-H727 is sensitive to Everolimus, in terms of cell viability reduction, while the atypical human BC cell line NCI-H720 is not. However, the mechanisms underlying this phenomenon have not been fully clarified.
Conference:
11th Annual ENETSConcerence (2014)
Presenting Author:
Authors:
Benfini K,
Gagliano T,
Gentilin E,
Minoia M,
Molè D,
Keywords:
BC,
mTOR,
#894
The Effects of cAMP in Different Neuroendocrine Tumorous Cells: The Role of Epac and PKA in Cell Proliferation and Cell Adhesion
Introduction:
cAMP is implicated in the inhibition or stimulation of proliferation depending on cell type. Although the effects exerted by cAMP were initially attributed to the PKA activation, two cAMP-activated guanine nucleotide exchange (Epac1/2) have been later identified as cAMP targets.
Conference:
11th Annual ENETSConcerence (2014)
Presenting Author:
Authors:
Vitali E,
Zerbi A,
Peverelli E,
Mantovani G,
Cambiaghi V,
Keywords:
cAMP,
PKA,
EPAC,
GEP-NET,
#87
Alterations of E-cadherin, beta-catenin and caveolin-1 expression in gastroenteropancreatic neuroendocrine tumors
Introduction:
Gastroenteropancreatic neuroendocrine tumors (GEP NETs) comprise a heterogeneous group of neoplasm with different histological patterns and biological behavior. Only limited information is available on immunohistochemical prognostic factors of disease. Alterations in the cell-cell adhesion system are closely associated with cell invasion and metastasis in many malignancies, including those of endocrine origin. Abnormal expression of E-cadherin and beta-catenin has been reported to play an important role in these processes. Caveolin-1 has recently been identified as a tumor metastasis modifier factor, which might increase the cell metastasis potential through the interaction with E-cadherin. However, the role of caveolin-1 in GEP NETs cell invasion remains unknown.
Conference:
7th Annual ENETSConcerence (2010)
Presenting Author:
Authors:
Delektorskaya V,
Chemeris G,
Keywords:
immunohistochemistry,
E-cadherin,
beta-catenin,
caveolin-1,
cyclin D1,
Ki67,
gastroenteropancreatic neuroendocrine tumors,
metastasis,
