Abstract Library

#4543 Single-cell transcriptomic landscape indicates the potential role of immunotherapy in metastatic pancreatic angiosarcoma

Introduction: Pancreatic angiosarcoma is a rare and highly aggressive tumour originated from lymphatic or vascular endothelial cells, with poor prognosis and few effective treatments. However, little is known about its tumour microenvironment and the mechanisms of its progression.

Conference:

Presenting Author: Yang Y

Authors: Yang Y, Chen L, Liu M, Lin X, Peng S,

Keywords: pancreatic angiosarcoma, single-cell RNA sequencing, immunotherapy, PD-L1, CD86,

#4534 Development of new 3D in vitro models for pancreatic neuroendocrine tumours (PanNETs)

Introduction: Current PanNET in vitro models struggle to accurately replicate the tumour’s biology and microenvironment, limiting understanding of the mechanisms underlying PanNET behaviour and drugs response.

Conference:

Presenting Author:

Authors: Battistella A, Pinos R, Barbaglio F, Capurso G, Schiavo Lena M,

Keywords: Preclinical models, Pan NET, microenvironment, bioprinting, tumour slices, drug testing,

#4424 Tumour-derived apolipoprotein E induces tip endothelial cell to remodel tumour stroma ratio and promote pancreatic neuroendocrine tumour progression

Introduction: Current clinical trials have shown that single-targeted matrix administration does not improve patient prognosis. The investigation of targeted matrix administration in combination with other therapies is crucial for effectively managing TSR in pNETs.

Conference:

Presenting Author: Ji S

Authors: Lou X, Ji S, Xu X, Chen J, Yu X,

Keywords: APOE, pancreatic neuroendocrine tumour, endothelial cell, tumour stroma ratio, mTOR inhibitor,

#2237 99mTc-Colloid Scintigraphy in the Differential Diagnosis of Pancreatic NET

Introduction: An accessory spleen (AS), a benign and congenital condition, is characterized by a small nodule of splenic tissue found outside of the spleen, which can mimic a pancreatic neoplasm (p-NET). 68Ga-PET/CT is used to study lesions suspected for NET, but the radioactive tracer binds also the reticuloendothelial cells, resulting in false positives in case of AS.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Chiloiro S

Authors: Chiloiro S, Mirra F, Donfrancesco F, Bianchi A, Bima C,

Keywords: 99mTc-colloid scintigraphy,

#1705 Prostate-Specific Membrane Antigen (PSMA) Uptake in a Pancreatic Neuroendocrine Tumor (pNET) Bearing Patient

Introduction: Prostate-specific membrane antigen (PSMA) is a transmembrane protein overexpressed on both prostate epithelial malignant cells and endothelial cells of tumor-associated neovasculature of many solid cancers. PSMA has been investigated already as a target in staging and detection of prostate cancer

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Grego E, Antista M, Pellicciari M, Ortolani S, Cingarlini S,

Keywords: PSMA, Ga PSMA PET/CT scan, pNET,