Abstract Library

#2269 Can Insulin-Like Growth Factor 1 (IGF-1), IGF-1 Receptor, Connective Tissue Growth Factor and Ki-67 Labelling Index Have a Prognostic Role in Pulmonary Carcinoids?

Introduction: Altered expression of Insulin-like Growth Factor-1 (IGF-1), its receptor (IGF-1R), Connective Tissue Growth Factor (CTGF) and Hypoxia Factor-1 (HIF-1), has been implicated in tumorigenesis. These factors have not been studied systematically in Pulmonary Carcinoids (PCs).

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author:

Authors: Tsolakis A, Kanakis G, Grimelius G, Papaioannou D, Kaltsas G,

Keywords: IGF-1, IGF-1R, CTGF, HIF-1, Ki-67,

#2248 High Grade (G3) Gastro-Entero-Pancreatic Neuroendocrine Neoplasms: Should the New WHO Classification Apply to All?

Introduction: Grade 3 (G3) neuroendocrine neoplasms (NEN), arising from the gastro-entero-pancreatic system (GEP), are classified according to WHO 2010 and defined as having a Ki67 of > 20%. However this groups together G3 well differentiated neuroendocrine tumours (WD-NET) with poorly differentiated neuroendocrine carcinomas (PD-NEC). Recently, WHO have proposed a new classification for pancreatic NEN, with sub-division into G3 WD-NET and G3 PD-NEC

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Furnace M

Authors: Furnace M, Muller G, Rundell C, Shah R, Luong T,

Keywords: G3, well-differentiated, poorly differentiated, Ki-67,

#2120 One Year Experience with Lutetium-DOTATATE for Disseminated NETs in the Gregorio Marañon Hospital

Introduction: The main curative therapy for NET is surgical resection when the disease is localized. But high percentage of patients is diagnosed with advanced disseminated disease and the peptide receptor radionuclide therapy (PRRT) with somatostatin analogs (SSA) is an emerging effective treatment.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Picallo P

Authors: Picallo M, Percovich J, García Centeno R, Rotger A, Colon A,

Keywords: Neuroendocrine, Lutetium, Radionuclide therapy,

#1859 The Prevalence of Intestinal Metaplasia in Patients with Gastric Neuroendocrine Neoplasms Type 1

Introduction: Intestinal metaplasia (IM) of the gastric mucosa is a relatively frequent precancerous lesion.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Boutzios G, Alexandraki K, Mavroeidi V, Thomas D, Kaltsas G,

Keywords: Intestinal metaplasia, gastric neuroendocrine neoplasms type 1,

#1739 A Kinomic Approach to Identify Signaling Proteins Involved in Drug Resistance in GastroEnteroPancreatic Neuroendocrine Tumors

Introduction: Most of the current therapeutic strategies used for neuroendocrine tumors (NETs) result in tumour growth stabilization, eventually followed by tumour progression. Thus, despite their original characteristics, NETs exhibit similar resistance features to treatments than other more common tumours.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Romano D

Authors: Romano D, Gerard C, Mondielli G, Lisbonis C, Niccoli P,

Keywords: Neuroendocrine Tumors, Drug resistance, Proteomics, Kinases,