Abstract Library

#4393 Surufatinib plus trans arterial embolisation (TAE) vs. surufatinib monotherapy in neuroendocrine tumour with liver metastasis: Updated results from the prospective, randomised, controlled trial

Introduction: The liver is the main metastasis site for NETs. Surufatinib (SUR), an oral TKI, is standard therapy for advanced NETs. TAE is the primary local intervention for unresectable hepatic NETs.

Conference:

Presenting Author: Cao D

Authors: Cao D, Li X, You X, Li R, Xiang J,

Keywords: NET, Liver metastasis, Surufatinib, TAE,

#4185 Primary hepatic neuroendocrine neoplasms – Clinical characteristics and treatment outcomes of a rare disease

Introduction: Liver involvement in Neuroendocrine Neoplasms (NEN) most commonly encompasses metastases from other organs or from an unknown primary. The current WHO classification defines primary hepatic NEN (PHNEN) as a distinct entity. With only few cases of PHNEN reported and difficulty to discern them from hepatic metastases, evidence on optimal management is very limited.

Conference:

Presenting Author:

Authors: Apostolidis L, Kender Z, Flegka V, Winkler E, Krug S,

Keywords: hepatic NEN, liver NEN, PHNEN,

#4142 Metastatic insulinoma – A clinical conundrum

Introduction: We present a case series of metastatic insulinoma from a single tertiary referral centre, highlighting heterogeneity in presentations, management, and multimodal therapy.

Conference:

Presenting Author:

Authors: Mathara Diddhenipothage S, Matheou M, Wilson S, Naseer A, Moore N,

Keywords: Metastatic insulinoma, hepatic metastases, peri-lesional steatosis,

#4112 Sexual dimorphism in small intestinal NETs: Any association with development of mesenteric metastases?

Introduction: Small-intestinal neuroendocrine tumors (SI-NET) are rising in incidence and complications such as mesenteric and hepatic metastases are associated with increased morbidity and mortality. It has recently been suggested that mesenteric metastases risk increases in women around menopause.

Conference:

Presenting Author: Castanho Martins M

Authors: Hassan D, Bally D, Castanho Martins M, Hodgetts H, Rombouts K,

Keywords: small intestine, mesenteric metastases, mesenteric fibrosis, sexual dimorphism, sex hormone,

#4009 Hepatic metastatic model establishment of pancreatic neuroendocrine tumor by hemi-splenectomy

Introduction: The early diagnosis of pancreatic neuroendocrine tumor (pNET) patients is hard, and 60% patients are diagnosed with liver metastasis at the first visit to hospital. These patients are not suitable for surgery, which is the preferred and most effective option for pNETs. And liver metastasis promises worse outcome for patients.

Conference:

Presenting Author: Wang F

Authors: Wang F, Jing D, Zhou C, Qin Y, Chen J,

Keywords: Pancreatic neuroendocrine tumor, liver metastases, murine model, hemi-splenectomy, hepatic metastatic model,