Abstract Library

#4036 Metformin inhibits small intestinal neuroendocrine tumor proliferation in vivo

Introduction: Small intestinal neuroendocrine tumors (SI-NETs) are rare and slow-growing, with most patients being diagnosed at a late stage with distant metastases. Metformin has been hypothesized as a potential anti-tumor agent by several studies in the past few years. This has been further confirmed by experimental studies in which metformin has inhibited cancer cell growth in different cancers, and we recently demonstrated that metformin treatment repressed the cell viability of SI-NET cells and inhibited the proliferation of cell spheroids.

Conference:

Presenting Author:

Authors: Axling F, Hellman P, Norlén O, Stålberg P, Barazeghi E,

Keywords: neuroendocrine neoplasm, SI-NET, in vivo model, metformin, RNA-seq, miRNA-seq, xenograft,

#3724 Tackling drug activity and resistance mechanisms in neuroendocrine tumors treated with cabozantinib

Introduction: Neuroendocrine tumors (NETs) are highly vascularized malignancies and angiogenesis plays a relevant role in cell proliferation and survival. Nowadays, innovative therapies have amplified the paradigm treatment of NETs. Among the compounds with anti-vascular properties, cabozantinib (CAB) appeared promising.

Conference:

Presenting Author: Cella C

Authors: Cella C, Cazzoli R, Fazio N, de Petro G, Gaudenzi G,

Keywords: Neuroendocrine tumor, angiogenesis, zebrafish model, mouse model.,

#3463 Jagged 1 restrains malignant progression in pancreatic neuroendocrine neoplasia

Introduction: Notch pathway is a pivotal regulator of pancreatic organogenesis and postnatal maintenance, yet its role in pancreatic neuroendocrine neoplasias (pNENs) remains ill-defined.

Conference:

Presenting Author:

Authors: Paramonov V, Mamaeva V, Laiho I, Kronqvist P, Vázquez-Ulloa E,

Keywords: pancreatic neuroendocrine tumor/neoplasia, Notch pathway, Jagged 1,

#3280 A patient derived organoid model of neuroendocrine neoplasms enables long-term growth in vitro of low grade tumors and reveals therapeutic vulnerabilities

Introduction: A paucity of in vitro and in vivo models has limited the study of neuroendocrine neoplasms (NENs).

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Dayton T

Authors: Dayton T, Alcala N, Den Hartigh L, Moonen L, Levy S,

Keywords: organoids, growth factor dependencies, lung NETs,

#3275 MicroRNA prognostic signature in neuroendocrine neoplasias (NENs) of lung and GEP origin: In silico analysis of target genes and pathways

Introduction: Molecular knowledge of NENs has increased in the last years. Nevertheless, the lack of in vivo models makes it difficult to guide functional experiments to better understand the biological implications of described molecular alterations. In this context, and as miRNAs contribute to regulate gene expression, we performed an in silico analysis to explore target genes and involved pathways regulated by an 8-miRNA prognostic signature that we recently developed in NENs, that stratified patients in 3 prognostic groups (Espinosa-Olarte P et al, ESMO 2020).

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author:

Authors: Espinosa Olarte P, Soldevilla B, Carretero-Puche C, Molina-Pinelo S, Robles C,

Keywords: neuroendocrine neoplasia, miRNAs, genes, pathways, prognosis,