Abstract Library

#4180 Non-functional alpha-cell hyperplasia with glucagonoma: A case report

Introduction: Alpha-cell hyperplasia(ACH) is a rare pancreatic endocrine condition. Clinically, 3 types have been described: functional ACH (nonglucagonoma hyperglucagonemic glucagonoma syndrome), reactive ACH (secondary to defective glucagon signalling) and non-functional ACH. Few cases of ACH and non-functional pancreatic neuroendocrine tumors (pNET) have been reported and its aetiology remains poorly understood.

Conference:

Presenting Author: Santos A

Authors: Cidade Rodrigues C, Santos A, Calheiros R, Santos S, Matos C,

Keywords: alpha-cell hyperplasia, diabetes, glucagon, pancreas, neuroendocrine tumor,

#4127 A CT-based radiomics and deep learning signature for evaluating the somatostatin receptor 2 in non-functional pancreatic neuroendocrine tumors: A multicohort, retrospective study

Introduction: The diagnosis and treatment of Non-functional Pancreatic Neuroendocrine Tumor (NF-panNET) with unlabeled or labeled somatostatin analogues necessitate high expression of the somatostatin receptor subtype 2 (SSTR2), typically identified using PET or SPECT imaging. However, the application of PET or SPECT imaging is limited due to its low spatial resolution and unavailability in all units.

Conference:

Presenting Author:

Authors: Tang W, Wenchao G, Yinli C, Jie C,

Keywords: Non-functional Pancreatic Neuroendocrine Tumor, SSTR2, Radiomics, Deep-learning, CT,

#4056 High expression of ADAM15 in non-functional pancreatic neuroendocrine tumors is associated with high-density tumor-infiltrating neutrophils and predicts poor outcome

Introduction: Non-functional pancreatic neuroendocrine tumors (NF-PanNETs) displayed heterogeneous prognoses. Copy number variations (CNVs) of ADAM15 significantly increased in patients who underwent postoperative early recurrence. ADAM15 (a disintegrin and metalloproteinase 15) has been identified as a key molecule in progression and metastasis of many tumors, regulating immune infiltration. However, correlation between ADAM15 and NF-PanNETs remains unknown.

Conference:

Presenting Author:

Authors: Tang L, Ying Y, Peng M, Wang Y, Lou W,

Keywords: pancreatic neuroendocrine tumor, recurrence, metastasis, ADAM15, tumor-infiltrating neutrophils,

#4008 Mapping of lymph node metastasis in non-functional pancreatic neuroendocrine tumors: A retrospective analysis of 455 patients

Introduction: Radical surgery is the best and effective option for resectable pancreatic neuroendocrine tumor (pNET) patients. However, lymphadenectomy in pNET surgery remains controversial, especially for small tumors.

Conference:

Presenting Author: Wang F

Authors: Wang F, Jing D, Zhou C, Qin Y, Chen J,

Keywords: Pancreatic neuroendocrine tumor, Lymph node metastasis, Lymph node dissection, Metastasis rate, Lymph node,

#3944 Compare the optimal TNM staging of resectable functional and non-functional pancreatic neuroendocrine tumors

Introduction: At present, the European Neuroendocrine Tumor Society (ENETS) and the American Joint Committee on Cancer (AJCC) are two main tumor TNM staging systems. However, the ENETS and AJCC TNM staging systems are different in some aspects when applied to p-NETs.

Conference:

Presenting Author: Wang Z

Authors: Xie Z, Wang Z, Cao D, Ke N,

Keywords: p-NETs, ENETS stage, AJCC stage, prognosis,