Abstract Library

#4256 Epigenetic prediction of aging and metabolic traits provides insight into tumor biology in multi-focal ileal neuroendocrine tumors

Introduction: Approximately half of small intestinal neuroendocrine tumors (siNETs) are multifocal, and recent investigations into the genetic architecture of these tumors have found that they are not clonal. Due to the low mutational rate and slow growing nature of these small tumors, the ‘timing’ of the development of individual tumors has not been possible.

Conference:

Presenting Author:

Authors: Webster A, Makinen N, Ecker S, Beck S, Nakakura E,

Keywords: DNA methylation, Epigenetics, Multifocal Ileal Neuroendocrine Tumor, Multifocal Small Instestinal NET, Metabolic Traits,

#4183 Establishment of novel patient-derived preclinical models for neuroendocrine tumors

Introduction: Neuroendocrine tumors (NETs) arise in different organs and are heterogeneous with limited treatment options. Preclinical models established from patient tumor specimens enable precision oncology by assessing the response to various drug treatments.

Conference:

Presenting Author: Michael I

Authors: Kulathunga N, Wang Z, Li B, Li Y, Tsui H,

Keywords: preclinical models, patient-derived organoids, patient-derived xenografts, drug screening,

#4008 Mapping of lymph node metastasis in non-functional pancreatic neuroendocrine tumors: A retrospective analysis of 455 patients

Introduction: Radical surgery is the best and effective option for resectable pancreatic neuroendocrine tumor (pNET) patients. However, lymphadenectomy in pNET surgery remains controversial, especially for small tumors.

Conference:

Presenting Author: Wang F

Authors: Wang F, Jing D, Zhou C, Qin Y, Chen J,

Keywords: Pancreatic neuroendocrine tumor, Lymph node metastasis, Lymph node dissection, Metastasis rate, Lymph node,

#3499 Epigenetic ageing and metabolic traits of multi-focal ileal neuroendocrine tumors

Introduction: Approximately half of small intestinal neuroendocrine tumors (siNETs) are multifocal, and recent investigations into the genetic architecture of these tumors have found that they are not clonal. Due to the low mutational rate and slow growing nature of these small tumors, the ‘timing’ of the development of individual tumors has not been possible.

Conference:

Presenting Author: Webster A

Authors: Webster A, Mäkinen N, Ecker S, Beck S, Nakakura E,

Keywords: multifocal siNET, DNA methylation, epigenetic clocks,

#3437 Is non-operative management of small asymptomatic sporadic nonfunctioning pancreatic neuroendocrine tumors safe?

Introduction: The diagnosis of asymptomatic sporadic nonfunctioning pancreatic neuroendocrine tumors (NF-PNET) has increased significantly nowadays due to the widespread use of high-resolution imaging tests, which is why it is debated which should be the most appropriate management at the time of diagnosis, and how we should follow-up these patients.

Conference:

Presenting Author:

Authors: Polette D, Busquets J, Uribe C, Martínez-Carnicero L, Secanella L,

Keywords: pancreatic neuroendocrine tumor, conservative treatment, observation, small tumor,