#3120
Thinking and confusion about a well-differentiated grade 3 pancreatic neuroendocrine tumor
Introduction:
In WHO Classification of Digestive System Tumors (2019 edition), pancreatic NENs are divided into well-differentiated NETs (including G1, G2, G3) and poorly differentiated NECs mainly based on the mitoses and Ki-67. G3 pNET and pNEC should have more than 20 mitoses/10 HPFs or their Ki-67 should be higher than 20%. However, WHO didn't clearly distinguish the Ki-67 cut-off value between them, and only 55% was recommended.
Conference:
18th Annual ENETS Concerence (2021)
Presenting Author:
Ma Y
Authors:
Ma Y,
Song L,
Li X,
Yang M,
Wang F,
Keywords:
pancreatic neuroendocrine carcinoma,
pancreatic neuroendocrine tumor,
G3,
P53,
ATRX,
DAXX,
MEN1,
#2920
Mutation Spectrums Analysis of Colorectal Adenocarcinoma and Neuroendocrine Neoplasm Based on Same Genetic Background to Reveal Tumorigenesis
Introduction:
The tumorigenesis of neuroendocrine neoplasm (NEN) are still ambiguous. The therapies of NENs in colon or rectum refer to adenocarcinomas (AC) when tumor metastasis, but the response was unsatisfactory which inspired us to explore the mutation difference.
Conference:
17th Annual ENETSConcerence (2020)
Presenting Author:
Hu H
Authors:
Cai W,
Ge W,
Wu D,
Mao J,
Hu H,
Keywords:
Neuroendocrine neoplasm,
Tumorigenesis,
Mutation spectrums,
Colorectal,
#2781
Case Report: Whole Exon Sequencing of Primary Lesion and Metastatic Liver Lesion in Pancreatic Neuroendocrine Tumor
Introduction:
Pancreatic neuroendocrine neoplasms(NENs) are classified into neuroendocrine tumors (NET) G1, G2, G3, and neuroendocrine carcinoma (NEC), which are different pathogenesis. The two kinds of tumors that occurs in the same lesion in one patient is very rare. We found high grade neuroendocrine neoplasms(NENG3) with a diameter of 0.1 cm in a patient with a pancreatic NETG2 (1.7 cm in diameter). The cells were significant atypia with Ki67 index of 60%, focal necrosis, while metastatic nodules in the liver (12, 0.1-1.1 cm in diameter) were all high grade NENG3.
Conference:
17th Annual ENETSConcerence (2020)
Presenting Author:
Authors:
Shi Y,
Zhong D,
Li Y,
Niu Y,
Tan H,
Keywords:
pancreatic neuroendocrine neoplasms,
whole exon sequencing,
TRIOBP signaling pathway,
MDM4,
