Abstract Library

#2765 Role of Biomarkers in Disease Progression of NET

Introduction: Due to the non specific features of neuroendocrine tumors and lack of diagnostic biomarkers, the diagnosis is usually delayed and almost half of patients presenting with distant metastases

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Fatima A

Authors: Fatima A, Zaidi S,

Keywords: biomarker, CgB, CART, CgA,

#1582 Utility of Serum Chromogranin B Compared with Chromogranin A as a Biomarker in Japanese Patients with Pancreatic Neuroendocrine Tumors

Introduction: Currently, serum chromogranin A (CgA) is used as a biomarker for pancreatic neuroendocrine tumors (pNET); however, oral use of a proton pump inhibitor (PPI) and renal impairment can affect CgA.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Miki M, Ito T, Hijioka M, Kawabe K, Jensen R,

Keywords: Pancreatic neuroendocrine tumors, Chromogranin A, Chromogranin B,

#1248 Case Report of Recurrent VIPoma

Introduction: 51yr presented with 7 month diarrhoea&2 stone weight loss. All tests negative, only abnormality hypokalaemia. FGH profile: VIP raised>400, peptide histidine methionine>1000, GAWK of 250. Diagnosis of VIPoma. CT: 5cm mass tail & body of pancreas, no hepatic or adrenal lesions. Octreotide treatment started. Bowel frequency improved, hypokalaemia corrected. Octreotide scan showed uptake only in pancreas. Patient readmitted 5 months later hypokalaemic myopathy, K 1.7, surgical distal pancreatectomy & splenectomy completed. Histology: NET within pancreas, moderate cellular differentiation, variable mitotic rate.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author:

Authors: Mulcahy V, McStay M, Sizer B,

Keywords: VIPoma,

#1177 An Isolated Abnormal Chromogranin B Is Associated with Pancreato-Duodenal NETs and the Presence of Liver Metastases

Introduction: Chromogranin B (CgB) is a soluble secretory protein like chromogranin A (CgA) that has been reported to be elevated in patients with neuroendocrine tumours (NETs) but is not routinely assessed.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author:

Authors: Basuroy R, Sherwood R, Srirajaskanthan R, Ramage J,

Keywords: chromogranin A, chromogranin B, pancreas, duodenal, assay, liver metastases,

#866 Plasma Chromogranin B as a Marker of Tumor Burden and Radiological Progression in Neuroendocrine Tumors

Introduction: Chromogranin-B (CgB) is expressed in most neuroendocrine tumors (NETs), yet little is understood about its clinical utility as a biomarker.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Braude D, Bartholomew T, Rossi R, Garcia-Hernandez J, Mullan M,

Keywords: Chromogranin B, midgut NETs, pancreatic NET, progression,