Abstract Library

#3726 Inflammation based index and tumor heterogeneity on pretherapeutic 68Ga DOTATOC PET/CT predict outcome in midgut neuroendocrine tumor patients treated with 177Lu-oxodotreotide

Introduction: Peptide receptor radionuclide therapy with 177Lu oxodotreotide (LuPRRT) is a standard treatment for the management of patients with inoperable metastatic well-differentiated neuroendocrine tumors of the midgut (iNET). As LuPRRT becomes widely used for a heterogeneous population of NET patients, practical predictive biomarkers are needed. Inflammation based index (IBI) derived from serum C reactive protein and albumin is associated with progression free survival (PFS) and overall survival (OS) in patients with PRRT for NETs. Ga-68 DOTATOC PET/CT (DOTAPET) assessment of lesion heterogeneity was predictive for response to PRRT.

Conference:

Presenting Author: Vija L

Authors: Vija L, Dierickx L, Kanoun S, Texier J, Terroir M,

Keywords: LuPRRT, GaDOTA PET/CT, neuroendocrine tumor, outcome,

#3687 Lutetium-177 DOTATATE PRRT versus PRRT plus chemotherapy in metastatic well differentiated FDG-avid GEP-NETs – Results from a prospective cohort

Introduction: Combination therapy with PRRT and Capecitabine-Temozolomide (CAPE-TMZ) has benefited patients with FDG avid well-differentiated GEP-NETs.

Conference:

Presenting Author:

Authors: Puranik A, Rangarajan V, Shrikhande S, Ramaswamy A, Ostwal V,

Keywords: PRRT, capecitabine, temozolomide, FDG PET, DOTA PET,

#3541 Surgical treatment of type 1 gastric neuroendocrine tumors: A 20-years single center experience

Introduction: Gastric neuroendocrine tumors (g-NETs) are rare, differentiated and usually indolent lesions; they include 3 types based on their pathogenesis. Type 1 are usually treated endoscopically according to their size, depth of invasion and presence of lymph-node (LN) metastases, types 3 are generally treated surgically. There is no clear evidence of the most accurate staging strategy for regional LN metastases.

Conference:

Presenting Author: Bertani E

Authors: Colombo S, Fumagalli Romario U, Pisa E, Spada F, Fazio N,

Keywords: Pet, gastric neuroendocrine tumor, surgery,

#3378 Clinical impact of 68 GA DOTANOC PET CT and 18 F FDG PET CT in clinical management of WHO Grade 2 neuroendocrine tumors

Introduction: WHO well differentiated grade 2 NET is large subgroup with extensive tumor heterogeneity. Both FDG and DOTA PET CT are influential in the management of NET. We determine the clinical impact of dual tracer imaging in grade 2 NET.

Conference:

Presenting Author:

Authors: Kale S, Puranik A, Purandare N, Shah S, Agrawal A,

Keywords: grade 2 NET, DOTA, FDG, Mib index,

#3338 Utility of SSTR radioligands in imaging and treatment of paediatric GEP-NETs

Introduction: Metastasized gastroenteropancreatic neuroendocrine tumors (GEP-NETS) in paediatric patients

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Steyn R

Authors: Steyn R, Kolade O, Aldera A, Masoka B, Radebe B,

Keywords: SSTR, PRRT, paediatric, GEP-NET,