Abstract Library

#4258 Unanticipated heterogeneity in high-grade large-cell neuroendocrine carcinoma pinpoints cell sub-state specific therapeutic targets

Introduction: High-grade pancreatic neuroendocrine carcinoma (panNEC) pose challenges in terms of classification and treatment. While molecular genetics have made strides in deciphering significant inter-tumor heterogeneity, the extent of intra-tumoral heterogeneity and lineage plasticity remains unexplored.

Conference:

Presenting Author:

Authors: Debnath O, Detjen K, Berger H, Kirchner P, Marinoni I,

Keywords: PanNEC, Single cell RNAseq,

#3120 Thinking and confusion about a well-differentiated grade 3 pancreatic neuroendocrine tumor

Introduction: In WHO Classification of Digestive System Tumors (2019 edition), pancreatic NENs are divided into well-differentiated NETs (including G1, G2, G3) and poorly differentiated NECs mainly based on the mitoses and Ki-67. G3 pNET and pNEC should have more than 20 mitoses/10 HPFs or their Ki-67 should be higher than 20%. However, WHO didn't clearly distinguish the Ki-67 cut-off value between them, and only 55% was recommended.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Ma Y

Authors: Ma Y, Song L, Li X, Yang M, Wang F,

Keywords: pancreatic neuroendocrine carcinoma, pancreatic neuroendocrine tumor, G3, P53, ATRX, DAXX, MEN1,

#2936 Mutational Landscape of 109 High-Grade Gastroenteropancreatic Neuroendocrine Neoplasms G3

Introduction: Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) G3 are rare with a poor outcome. Molecular data for GEP NEN G3 is limited and the 2019 WHO classification is based on morphology and proliferation rate.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Elvebakken H

Authors: Venizelos A, Elvebakken H, Perren A, Hjortland G, Sundlöv A,

Keywords: molecular genetics, neuroendocrine carcinoma, neuroendocrine tumors, gastroenteropancreatic, mutations,

#1523 Multiregion Analysis Reveal Evolutionary Patterns and a Chromosomal Instability Signature in Pancreatic Neuroendocrine Tumours

Introduction: Pancreatic neuroendocrine tumors (PNETs) are potentially lethal diseases that show variable degrees of proliferation and invasiveness. Although genetic subgroups have been suggested to give prognostic information the impact of clonal evolution to the development and outcome of PNETs remains unexplored.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Crona J

Authors: Crona J, Backman S, Kugelberg J, Maharjan R, Björklund P,

Keywords: Cancer evolution, Molecular genetics, Neuroendocrine Tumor,