Abstract Library
Welcome to the open-access search for all ENETS abstracts presented at the Annual ENETS Conferences.
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Introduction: Studies have shown that curcumin regulates malignant tumors through many important signalling pathways, such as Ras, P13K, p53, AKT, mTOR, Wnt-catenin, etc. Regarding the research on the molecular target mechanism of curcumin inhibiting pancreatic neuroendocrine tumors, there is a lack of relevant data at home and abroad. The proven antitumor potential targets of curcumin were intersected with the proteins present in pancreatic neuroendocrine tumor QGP-1 cells, and AKT/mTOR was selected as the central content of this study.
Conference:
Presenting Author: Han D
Keywords: Curcumin, Pancreatic neuroendocrine tumor cells, Mechanism,
#3595 Effects of curcumin on proliferation of pancreatic neuroendocrine tumor cells
Introduction: Medical studies have shown that curcumin has the effects of lowering blood lipids, anti-tumor, anti-inflammatory, choleretic and antioxidant. In recent years, domestic and foreign studies have reported that curcumin has an increasingly prominent effect on inhibiting the proliferation of tumor cells, but the effect of curcumin on pancreatic neuroendocrine tumor cells has not been studied.
Conference:
Presenting Author: Han D
Keywords: Curcumin, Pancreatic Neuroendocrine Tumor, Cells, Inhibitors,
Introduction: Pancreatic neuroendocrine tumors (PNETs) are slow growing, but often metastasize to the liver. Several systemic treatment options are available for metastatic PNETs but unfortunately fail to improve survival. Hence a better understanding of PNET biology and new therapies are required. In an attempt to identify new drugs for metastatic PNETs, our group performed gene expression analysis of primary PNETs and PNETs that metastasized to lymph nodes and/or liver and identified genes and drug candidates that could potentially help treat metastatic PNETs.
Conference: 18th Annual ENETS Concerence (2021)
Presenting Author: Tran C
Authors: Tran C, Li G, Sherman S, Howe J, Ear P,
Keywords: PNET, metastases, drug resistance, liver microenvironment, etoposide, CYP3A4,
#2030 Autophagy Process in Pancreatic Neuroendocrine Tumor Cells
Introduction: Pancreatic neuroendocrine malignancy is rising up in the last decade. Despite surgical resection and palliative therapy, an effective therapy has not been developed yet.
Conference: 15th Annual ENETSConcerence (2018)
Presenting Author: Matrood S
Authors: Matrood S, Wissniowski T, Wiese D, Buchholz M, Gress T,
Keywords: autophagy, pancreatic neuroendocrine tumor, AMPK-alpha,
#2001 The Anticancer Mechanism of Metformin in Pancreatic Neuroendocrine Tumor Cells
Introduction: Metformin, a widely used antidiabetic drug, has been reported to display potent anticancer properties in various types of cancers. In P-NETs, aryl hydrocarbon receptor-interacting protein (AIP) acts as a tumor suppressor and is up-regulated by the somatostatin analog octreotide.
Conference: 15th Annual ENETSConcerence (2018)
Presenting Author: Lania A
Authors: Vitali E, Piccini S, Boemi I, Brambilla T, Zerbi A,