Abstract Library

#4560 Genetic trajectory and clonal evolution of non-functional pancreatic neuroendocrine tumours with lymph node and liver metastasis

Introduction: The systemic spread of panNETs is dominated by lymphatic reflux and portal system, exhibiting diverse patterns of metastasis without systematical genomic investigation.

Conference:

Presenting Author: Wu J

Authors: Wu J, Peng Y, Yin L, Jiang K, Li Q,

Keywords: Pan NET, Metastasis, Whole exome sequencing, Pylogenic tree,

#4381 TOPK promotes tumorigenesis and metastasis of pancreatic neuroendocrine neoplasms by enhancing the MAPK signalling pathway

Introduction: T-LAK cell-originated protein kinase (TOPK) is highly expressed in pancreatic neuroendocrine neoplasms (pNENs) with liver metastasis and is associated with a poor prognosis.

Conference:

Presenting Author: Chen Q

Authors: Chen Q, Yuan M, Meng M, Ren S, Li G,

Keywords: TOPK, Pancreatic Neuroendocrine Neoplasm, MAPK signalling pathway, Invasion and metastasis, HI-TOPK-032,

#4307 Predictive value of pepsinogen I and I/II ratio for diagnosing autoimmune gastritis

Introduction: Autoimmune gastritis (AIG) is sometimes difficult to diagnose.

Conference:

Presenting Author:

Authors: Hu H, Chen C, Zhang Q, Li P,

Keywords: autoimmune gastritis, pepsinogen 1, pepsinogen 1/2 ratio, gastrin,

#3654 Digital image analysis of Ki-67 heterogeneity of pancreatic neuroendocrine neoplasms with or without liver metastasis

Introduction: Ki-67 is a reliable grading and prognostic biomarker of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs). The application of digital image analysis (DIA) enables new digital biomarkers in the assessment of Ki-67 heterogeneity distribution. Our previous study reported that the Morisita-Horn (MH) index, an ecological marker for the measurement of spatial colocalization variants, directly correlated with classification and grading in GEP-NENs and provided prognostic information.

Conference:

Presenting Author: Huang D

Authors: Zhang M, Han X, Ding X, Zhang B, Wang Y,

Keywords: pancreatic, Ki-67 heterogeneity, liver metastasis, Digital image analysis,

#3072 Rb and p53 Status Determination by Immunochemistry Is Complementary in Routine Practice to Genetic Testing of Neuroendocrine Neoplasms

Introduction: Rb and p53 status may help distinguishing well from poorly differentiated neuroendocrine neoplasms (NEN) and may predict response to chemotherapy. Studies correlating Rb/p53 genetic and immunohistochemistry were performed on high-quality frozen samples with high throughput techniques efficient for copy number determination. This situation differs from routine practice in which small deletions may be hard to detect on formalin-fixed paraffin-embedded (FFPE) samples with a gene panel approach.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Cros J

Authors: Chen R, Lacroix L, De Rycke O, Lacombe C, Cazes A,

Keywords: rb, p53, aggressive neuroendocrine tumors, biomarker,