Abstract Library

#4588 Spatial transcriptomics identifies Wnt signalling in multifocal ileal neuroendocrine tumours

Introduction: Ileal neuroendocrine tumours (i-NETs) often present with multiple primary tumours (>30-40%). Recent studies showed no shared somatic mutations in multiple primary tumours, highlighting the need to examine the tumour microenvironment in tumorigenesis. The Wnt signalling pathway is crucial for organ stem cell regulation. While the Wnt/β-catenin pathway influences prostate and pancreatic NET/Cs, its role in i-NETs remains unclear.

Conference:

Presenting Author:

Authors: Yogo A, Akanuma N, Kim G, Thirlwell C, Mäkinen N,

Keywords: Wnt Signalling, Spatial Transcriptomics,

#4539 Single-nucleus profiling of the tumour microenvironment in SI-NET patients

Introduction: Small intestinal neuroendocrine tumours (SI-NETs) are frequently present as multiple synchronous primary tumours in the small bowel. They are thought to arise from enterochromaffin (EC) cells in the gut, which account for less than 1% of the intestinal epithelium. Previously reported lack of shared somatic driver alterations in SI-NETs suggests that other, non-genetic mechanisms are likely involved in their tumorigenesis.

Conference:

Presenting Author: Mäkinen N

Authors: Mäkinen N, Kasai Y, Kim G, Thirlwell C, Nakakura E,

Keywords: small intestinal NET, tumour microenvironment, single-nucleus sequencing,

#4242 Sequential Everolimus and Sunitinib treatment in progressive, advanced, pancreatic NENs: Real-world data from the Belgian Group of Digestive Oncology DNET & NETwerk

Introduction: Everolimus and Sunitinib are often used consecutively for advanced, progressive, well-differentiated pancreatic neuroendocrine tumors (pNET), but to date no data on the optimal sequence is available.

Conference:

Presenting Author: Islam O

Authors: Islam O, van de Vyver G, Verslype C, Borbath I, Decaestecker J,

Keywords: pNEN, Everolimus, Sunitinib, mPFS, mOS, AEs,

#3840 Sneak peek into neuroendocrine tumors (preliminary study) – Reconsideration of histopathological approach and classification

Introduction: Tumorlets and DIPNECH are rare entities often associated with bronchial neuroendocrine tumors and little is known regarding their clinical course and management. However, they are not uncommon findings on CT or MR imaging of patients with known bronchial NENs.

Conference:

Presenting Author:

Authors: Vamvakaris I, Evangelou G, Riga D, Jensen L, Psichoyou E,

Keywords: TUMORLETS, DIPNECH, TYPICAL CARCINOID, ATYPICAL CARCINOID, LUNG NET, BRONCHIAL NET, CLASSIFICATION,

#3651 Mesenteric fibrosis in small intestinal neuroendocrine tumors (SI-NETs) – Steps towards understanding its pathogenesis

Introduction: Mesenteric fibrosis (MF) occurs in 50% of patients with SI-NETs, causing significant morbidity and mortality. The pathogenesis of MF in SI-NETs is incompletely understood with no biomarkers or radiological criteria to predict long-term complications of SI-NET associated MF.

Conference:

Presenting Author:

Authors: Hodgetts H, Martins M, Luong T, Hall A, Thirlwell C,

Keywords: small, intestine, neuroendocrine tumor, fibrosis, mesenteric, rna-sequencing, biomarker,