Abstract Library

#4423 Exploring decorin in plasma-derived small extracellular vesicles (sEVs) as a potential diagnostic biomarker for pancreatic neuroendocrine tumours

Introduction: Pancreatic Neuroendocrine tumours (PanNETs), the most common site for GEP‑NENs in Asian countries, particularly India, have shown increasing incidence. Due to a lack of specific biomarkers, often detected at advanced stages. So, this study utilised PanNET tissue proteomics for cancer biomarker discovery and explored the impact of small extracellular cellular vesicles (sEVs) in PanNET growth and metastasis, as they reflect the molecular profile of their tissue of origin.

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Presenting Author:

Authors: Gorai P, As S, Naik M, Kumar S, Pal S,

Keywords: Decorin, small extracellular vesicles, Pancreatic Neuroendocrine Tumour, Proteomics, circulating biomarker,

#4406 Fluorescence labelled plasma derived small extracellular vesicle as biomarkers in metastatic pancreatic neuroendocrine tumour patients

Introduction: Pancreatic neuroendocrine tumours (PanNET) are rare with increased annual incidence rate 1/lac. There are no specific biomarkers, diagnostic and prognostic tests available for PanNET. The small extracellular vesicles (sEV) play a key role in tumour growth and metastasis and can be a potential biomarker for metastasis of PanNET.

Conference:

Presenting Author:

Authors: As S, Gorai P, Naik M, Kumar R, Kumar S,

Keywords: Metastasis, Pancreatic neuroendocrine tumour, Small extracellular vesicles, Fluorescence, Nanoparticle tracking analysis,

#3974 Small extracellular vesicles miR-183-5p derived from highly invasive pancreatic neuroendocrine tumors reprogram macrophages towards SPP1+ macrophages

Introduction: Highly-metastatic (HM) pancreatic neuroendocrine tumors (pNETs) are characterized by an early occurrence of lymph node and liver metastases and a poor prognosis. Single-cell sequencing analysis showed that HM pNETs had remarkable infiltration of SPP1+ macrophages, which were involved in cell migration, angiogenesis and small extracellular vesicles (sEVs).

Conference:

Presenting Author:

Authors: Zhang W, Xu J, Lou X, Qin Y, Chen J,

Keywords: pancreatic neuroendocrine tumor, p53, small extracellular vesicles, macrophages, SPP1, biomarker,

#3613 Plasma-derived small extracellular vesicles reveal pancreatic neuroendocrine tumors

Introduction: The incidence of pancreatic neuroendocrine tumors (PNETs) has increased over the past 30 years worldwide. The survival rate is low due to the diagnosis being done at a higher stage and unavailability of specific and sensitive diagnostic markers. Hence, better and efficient early diagnostic biomarkers are required at the earliest. As the role of small extracellular vesicles (sEV) in tumor growth and cancer metastasis is increasing exponentially due to its capability to cause metastasis and proliferation. For the first time, this study establishes the relationship between sEV concentration and PNET grades as well as the presence of BIRC2/cIAP as sEV cargo derived from plasma.

Conference:

Presenting Author: Gorai P

Authors: Gorai P, Rastogi S, Soni P, Singh S, Agarwal S,

Keywords: pancreatic neuroendocrine tumor, small extracellular vesicles, BIRC2/cIAP, early diagnostic biomarker,