Abstract Library

#3006 Teratoma with Malignant Transformation: A Case Report of a Neuroendocrine Tumor That Arises from the Bronchial Mucosa in a Mature Cystic Teratoma

Introduction: Mature cystic teratoma (MCT) is the most common type of germ cell tumor in the ovary. A malignant tumor that arises in a pre-existing mature teratoma is called teratoma with malignant transformation (TMT).

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Espinola Benza M

Authors: Espinola Benza M, La Salvia A, Hernandez Sanchez L, Gallardo Gallego R, Suarez Pita D,

Keywords: Mature cystic teratoma, teratoma with malignant transformation, surgical resection,

#2842 Transformation to High Grade 3 (G3) Neuroendocrine Neoplasia (NEN) – Molecular Imaging, Pathologic Features and Patient Outcomes

Introduction: Transformation of lower grade to Grade 3 (G3) NEN potentially impacts prognosis & treatment options.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Kong G, Callahan J, Prall O, Michael M, Hicks R,

Keywords: Transformation, G3 NEN, PET imaging, mutation, PRRT, prognosis,

#2811 Improving Diagnosis Times as Part of the Transformation of the South Wales NET Service

Introduction: Transformation of the South Wales NET service in late 2017 introduced new specialised staff, gastroenterology-led clinics and improved MDTs with a particular emphasis on educating referring specialties. This has led to improved overall patient experience, satisfaction and quality of life. NETs are recognised world-wide for their lengthy diagnosis times.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Amin K

Authors: Amin K, Gruber M, Shayan-Arani H, Taylor R, Powell C,

Keywords: neuroendocrine, tumours, diagnosis, survival, gastroenterology, surgery, new service, nets, south wales, midgut, pancreatic, paraganglioma, incidental,

#1890 Natural History of Type 1 Gastric Carcinoid (gNENs) and Risk of Adenoma/Adenocarcinoma in Endoscopic Surveillance Programme

Introduction: Patients with gNENs & autoimmune gastritis are exposed to 2 malignant risks: 1)transformation of gNENs, felt to be low & guidelines advocate either resection of all lesions or selective endoscopic mucosal resection(EMR) of larger lesions; 2)ill-defined risk of gastric adenoma/adenocarcinoma.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Chin J, O’Connell J, O’Mahony S, Van Boxel O, Muldoon C,

Keywords: Type 1 g-NENs,

#1555 Antitumor Activity of Desmopressin (dDAVP) and the New Analog [V4Q5]dDAVP in Human Small Cell Lung Cancer

Introduction: Lung cancer is the main cause of cancer death. Non small cell lung cancer (NSCLC) cause about 85% of cases and small cell lung cancer (SCLC) represents 15%. Therapy resistance is commonly related with a transformation from adenocarcinoma to SCLC. SCLC shows neuroendocrine (NE) features and exhibits aggressive behavior. In vitro production of vasopressin (AVP) was reported in SCLC. The AVP V1 receptors are associated with mitogenic signaling pathways, while AVP V2 receptor (V2r) is related with an opposite effect. DDAVP is a synthetic analog of AVP that acts as a selective agonist for V2r. DDAVP displays cytostatic and antimetastatic properties in breast and colorectal cancer. In our laboratory a new analog, [V4Q5]dDAVP, showed improved cytostatic activity

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author:

Authors: Pifano M, Garona J, Alonso D, Ripoll G,

Keywords: v2r, antitumor, NE,