Abstract Library

#4502 Molecular analysis of non-functioning PanNETs of the alpha lineage reveals new subtypes and mechanisms of progression

Introduction: Most pancreatic neuroendocrine tumours (PanNETs) are non-functioning. Previously, we demonstrated that small, MEN1-only mutated α-like PanNETs can be distinguished from larger ADM (mutated in ATRX, DAXX and MEN1) PanNETs based on epigenetic profiles. ADM PanNETs have shorter disease-free survival and a higher relapse risk. However, their therapeutic responses vary, underscoring group heterogeneity. ADM PanNETs remain insufficiently characterised, with potential subtype-specific progression drivers with implications for treatment choice and clinical outcome.

Conference:

Presenting Author: Avanthay S

Authors: Avanthay S, Di Domenico A, Kirchner P, Bräutigam K, Chouchane A,

Keywords: pancreas, epigenetics, progression, metastasis, DAXX, ATRX, Pan NET,

#4143 Portal vein resection in pancreatic neuroendocrine neoplasms

Introduction: Surgery offers the only cure in borderline resectable or locally advanced neuroendocrine neoplasms of the pancreas (pNEN). Data on incidence and postresection outcome of portal vein resection (PVR) for pNEN are scarce.

Conference:

Presenting Author: Nießen A

Authors: Nießen A, Klaiber U, Lewosinska M, Nickel F, Billmann F,

Keywords: venous resection, pancreatic neoplasia, pancreatic neuroendocrine tumor, pancreatic resection,

#3941 Association of body composition with survival in patients with Pancreatic Neuroendocrine Tumors (PNET) following curative resection

Introduction: The body composition has been demonstrated to be associated with the prognosis of various cancers. However, the prognostic value of body composition in patients with pancreatic neuroendocrine tumors (pNETs) following curative resection is still unknown.

Conference:

Presenting Author: Xie Z

Authors: Shen X, Wang Z, Liu X, Wang X, Xie Z,

Keywords: body composition, pNETs, computed tomography, survival,

#3927 Prognostic role and predictors of lymph node involvement in pancreatic neuroendocrine tumors

Introduction: Pancreatic neuroendocrine tumors (PNETs) account for less than 2% of all pancreatic neoplasms. However, the incidence of PNETs has been steadily increasing in recent years, possibly because the frequent use of high-quality abdominal cross-sectional imaging increased the detection rate.

Conference:

Presenting Author: Ren S

Authors: Ren S, Tan Q, Cao D, Ke N, Liu X,

Keywords: pancreatic neuroendocrine tumor, lymph node involvement, radiologic characteristic, prognostic factor,

#3734 Treatment outcomes in patients with localized and advanced glucagonomas – A case series

Introduction: Glucagonomas are rare functional pancreatic neuroendocrine tumors, which are often metastatic at diagnosis. Due to their low prevalence, the effectiveness of available treatment modalities remains unclear.

Conference:

Presenting Author: Armeni E

Authors: Porto J, Alexander B, Armeni E, Hesketh R, Mandair D,

Keywords: glucagonoma, treatment lines, progression-free survival, overall survival,