Abstract Library

#1637 The Effect of the Autophagy Inhibitor Chloroquine (CQ), Alone or in Combination with mTOR Inhibitors, on Neuroendocrine Tumor (NET) Growth and Metastatic Spread in Mouse Models

Introduction: mTOR inhibitors (mTORi) such as RAD001 demonstrated promising anti-cancer effect in NETs. Autophagy, a cell survival mechanism, is activated by mTORi. We have recently shown in the human NET cell line BON1 that autophagy is essential for cell survival. Treatment with CQ alone or together with mTORi robustly inhibited cell proliferation and survival, suggesting that treatment with CQ may potentiate the anti-tumorigenic effects of mTORi.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Avniel-Polak S

Authors: Avniel-Polak S, Leibowitz G, Gross D, Grozinsky-Glasberg S,

Keywords: autophagy, mTORi, NET,

#536 Orexins Exert a Pro-Apoptotic Effect on Neuroendocrine Tumors (NETs) in an Ex Vivo Culture Model of Tissue Slices

Introduction: Ex vivo culture models of tissue slices are suitable to test the effect of antitumor agents in human tumors. The orexins are neuropeptides binding to G protein-coupled receptors (OX1-R and OX2-R), exerting a pro-apoptotic effect in human colon and pancreatic cancer cell lines.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Palazzo M, Rebours V, Voisin T, Albuquerque M, Paradis V,

Keywords: digestive NET, orexins, apoptosis, ex vivo model,