Abstract Library

#4426 A case of giant neuroendocrine tumour of unknown primary site

Introduction: The liver is a common site for metastatic neuroendocrine tumours. NETs primary to the liver are rare, and it is difficult to determine whether a neuroendocrine tumour in the liver is primary or metastatic in patients in whom no tumour has been found elsewhere.

Conference:

Presenting Author: Yingmei T

Authors: Jieting D, Yanping Z, Yingmei T, Rongfang T, Yan W,

Keywords: neuroendocrine tumour, primary hepatic neuroendocrine tumour, metastatic,

#3845 The lungNENomics project – A comprehensive multidisciplinary characterisation of pulmonary carcinoids

Introduction: Lung neuroendocrine tumors (LNETs) are subdivided into low-grade (typical) and intermediate-grade (atypical) carcinoids, at higher risk of developing metastases. We have previously identified 3 LNETs molecular groups with different prognoses, as well as “supra-carcinoids” with molecular profiles of higher-grade neuroendocrine carcinomas. Despite promising results, there is still no consensus on their differential diagnosis and treatment and little is known about how some tumors evolve toward more aggressive phenotypes.

Conference:

Presenting Author:

Authors: Foll M, Sexton-Oates A, Mathian E, Alcala N, Mangiante L,

Keywords: lung carcinoid, deep learning, genomic, evolution, multi-omics, spatial analyses,

#3835 Druggable growth dependencies and tumor evolution analysis in patient-derived organoids of neuroendocrine cancer

Introduction: 28% of low-grade neuroendocrine tumors (NETs) present at advanced stages and are unresponsive to therapy, pointing to a gap in our understanding of how these tumors arise and progress.

Conference:

Presenting Author: Dayton T

Authors: Dayton T, Alcala N, Moonen L, den Hartigh L, Mangiante L,

Keywords: Organoids, LCNEC, NET, pulmonary carcinoid, EGF,

#3824 A rare clinical case of giant pituitary ACTH adenoma

Introduction: Cushing's disease is a neuroendocrine disease that is associated with ACTH-secreting pituitary microadenomas whereas macro- and giant adenomas are less common.

Conference:

Presenting Author:

Authors: Lastovkina A, Ilovaiskaya I, Komerdus I, Motrenko A, Zakharova P,

Keywords: Cushing's disease, giant corticotropinoma, hypercortisolism,

#3401 Characterising aggressive pulmonary carcinoids through integrative omics analysis

Introduction: Atypical carcinoids, and our recently identified supra-carcinoids (Alcala et al. 2019) belong to the pulmonary carcinoid (PCA) group of low grade lung neuroendocrine tumors. Little is known about the underlying biology of these tumors, nor why some patients are prone to metastatic disease and tumor recurrence. To date, molecular analysis of these tumors has been limited, particularly with regard to whole-genome sequencing (WGS).

Conference:

Presenting Author:

Authors: Sexton-Oates A, Di Genova A, Alcala N, Mangiante L, Voegele C,

Keywords: pulmonary carcinoid, genome, transcriptome, epigenome, characterisation,