Abstract Library

#2983 Differential TGF-β Signalling in Typical and Atypical Bronchial Carcinoids

Introduction: Typical and atypical bronchial carcinoids (TBC and ABC) are well-differentiated neuroendocrine neoplasms (NEN). Metastatic BC having low to moderate mitotic count may still be treated with somatostatin analogues and mTOR inhibitors; however, TBC and ABC have been reported to respond very differently to therapy and an effective treatment algorithm is still lacking. TGF-β is known for its ability to activate mTOR pathway and induce epithelial mesenchymal transition, affecting cell pathophysiological capabilities such as proliferation, migration and tissue invasiveness.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Borges de Souza P

Authors: Borges de Souza P, Tagliatti V, Capobianco S, Ambrosio M, Chinnici S,

Keywords: Neuroendocrine neoplasms, bronchial carcinoids, TGF-β,

#1560 Cannabinoids as Inhibitor of Tumour Growth and Invasiveness in Small Intestine Neuroendocrine Cancer

Introduction: Tumour cell invasion and proliferation is a key factor for the prognosis and progression of cancer. A recent study revealed that cannabinoids can inhibit tumour invasion and proliferation in breast cancer through the down-regulation of ID-1, an inhibitor of helix-turn-helix transcription factors.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Errampalli R

Authors: Errampalli R, Reicher A, Kleinegger F, Hirschnöck T, Pfragner R,

Keywords: si-net, id1, cannabinoid​,

#1523 Multiregion Analysis Reveal Evolutionary Patterns and a Chromosomal Instability Signature in Pancreatic Neuroendocrine Tumours

Introduction: Pancreatic neuroendocrine tumors (PNETs) are potentially lethal diseases that show variable degrees of proliferation and invasiveness. Although genetic subgroups have been suggested to give prognostic information the impact of clonal evolution to the development and outcome of PNETs remains unexplored.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Crona J

Authors: Crona J, Backman S, Kugelberg J, Maharjan R, Björklund P,

Keywords: Cancer evolution, Molecular genetics, Neuroendocrine Tumor,

#1428 Factors Affecting Recurrences of the Non-functioning Pancreatic NET After Resection

Introduction: In 2010, WHO classification has been modified. However, the usefulness of the criteria for surgeons has not been elucidated, because the criteria is defined by cell growth represented by Ki67 for overall survival and may not represent invasiveness of the tumor.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author:

Authors: Masui T, Sato A, Nakano K, Nakamoto Y, Matsumoto S,

Keywords: WHO2010, invasiveness,

#1115 Cancer Stem Cells in Small Intestine Neuroendocrine Cell Line P-STS: Isolation and Molecular Characterisation

Introduction: Cancer stem cells (CSCs) represent a small subpopulation of tumour cells responsible for invasive tumour growth. Even though the presence of CSCs in neuroendocrine tumours is documented, their role in neuroendocrine tumourigenesis and metastasis is not defined as yet.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author:

Authors: Kleinegger F, Meier-Allard N, Fuchs R, Hölzl M, Krump C,

Keywords: Cancer stem cells, tumor growth, tumorigenesis & metastasis,