Abstract Library

#4011 Differences in the microRNA expression of G1 and G2 pancreatic neuroendocrine tumors

Introduction: Targeted testing of microRNAs implicated in the biology of pancreatic neuroendocrine tumors (PNET) was performed via RT-QPCR to uncover differentially expressed microRNAs that could be used as diagnostic markers characteristic for tumor grade.

Conference:

Presenting Author:

Authors: Nyirő G, Szeredás B, Vékony B, Borka K, Zalatnai A,

Keywords: miRNA expression, PNET G1 and G2, RT-QPCR, hsa-miR-130b-3p, hsa-miR-194-5p, hsa-miR-96-5p, hsa-miR-106b, FFPE tissue,

#2128 Epigenetic Changes in DAXX and/or ATRX Negative Pancreatic Neuro-Endocrine Tumors

Introduction: The most commonly mutated genes in Pancreatic Neuroendocrine Tumors (PanNETs) are MEN1, DAXX and ATRX, which encode for proteins involved in epigenetic regulation. DAXX/ATRX mutated PanNETs are globally hypomethylated and behave clinically in a more aggressive way. Tumor pathways associated with these changes are still unclear. We hypothesize that DAXX/ATRX and MEN1 mutations mediate PanNET progression via epigenetic dysregulation.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Di Domenico A

Authors: Di Domenico A, Pipinikas C, Simillion C, Wiedmer T, Maire R,

Keywords: methylation, expression, miRNA, epigenetic, PanNETs, neuroendocrine, tumors, MEN1, DAXX, ATRX, progression,

#2086 miRNA Expression Defines Novel Subgroups of Small Intestinal Neuroendocrine Tumors

Introduction: Epigenetic dysregulation frequently occurs in cancers. Here we present the largest survival related miRNA profiling study to date of small intestinal neuroendocrine tumors (SI-NETs).

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author:

Authors: Arvidsson Y, Rehammar A, Bergström A, Andersson E, Altiparmak G,

Keywords: neuroendocrine tumor, small intestine, miRNA, profiling, cluster analysis, survival, miR-375, B-catenin,

#954 Specific MicroRNA Profiles are Associated with Pathological Features in Lung Carcinoids

Introduction: Data on miRNA expression in lung carcinoids are scarce.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: Volante M

Authors: Rapa I, Votta A, Felice B, Righi L, Giorcelli J,

Keywords: lung, carcinoid, miRNA,

#807 MicroRNA Expression in Serum of Small Intestine Neuroendocrine Tumor Patients and miR-196a Biological Function in Neuroendocrine Tumor Cells

Introduction: We have previously identified five upregulated and four downregulated miRNAs in small intestinal neuroendocrine tumor (SI-NET) tissue. We extended our analysis to serum samples of SI-NET patients to depict miRNAs functions.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: Li S

Authors: Li S, Khan M, Caplin M, Öberg K, Meyer T,

Keywords: neuroendocrine tumors, serum miRNA expression, miRNA, target functions ,