Abstract Library

#4157 Decoding and targeting of metabolic heterogeneity in pancreatic neuroendocrine tumors (PanNETs): MCT1 and MCT4 in the crosshair for precision therapy

Introduction: Mechanisms driving progression from indolent to aggressive and metastatic disease in PanNET are largely unknown. Recent transcriptome and epigenome analyses suggest a stepwise progression model leading to enhanced proliferation, de-differentiation, and metabolic reprogramming. However, the metabolic landscape at different stages and the therapeutic potential of targeting metabolic proteins remain largely uncharacterized.

Conference:

Presenting Author: Sadowski M

Authors: Bräutigam K, Straub J, Bihi A, Andreasi V, Kirchner P,

Keywords: metabolic heterogeneity, 3D model, precision medicine, metabolic subtype, PanNET, hypoxia, lactate efflux, microvessel density, MCT1/MCT4,

#3725 Progression of pancreatic neuroendocrine tumors (PanNETs) to metastatic disease is associated with MCT4 expression and metabolic heterogeneity

Introduction: Up to 50% of patients with PanNETs present with metastasis at time of diagnosis or relapse after surgery, with highly variable dynamics. The mechanisms driving progression from indolent to metastatic disease are largely unknown. Although having great potential for providing novel therapeutic targets, the metabolic landscape at different tumor stages is only poorly understood. Transcriptome and epigenome analyses of PanNET indicate a potential stepwise progression, which is associated with enhanced proliferation, dedifferentiation and hallmarks of hypoxia.

Conference:

Presenting Author: Sadowski M

Authors: Sadowski M, Bräutigam K, Straub J, Andreasi V, Kirchner P,

Keywords: MCT4, metabolic subtypes, aggressive PanNET, patient-derived tumoroid,

#3581 Pancreatic neuroendocrine tumors (PanNETs) vascularization: From “micro” to “macro”

Introduction: Density of microvessels in pancreatic neuroendocrine tumors (PanNETs) changes according to their biological behaviour. Differently from other non-neuroendocrine cancers, a low microvessel density (L-MVD) is associated with higher disease aggressiveness and poorer prognosis.

Conference:

Presenting Author:

Authors: Battistella A, Andreasi V, Palumbo D, Tacelli M, de Cobelli F,

Keywords: pancreatic neuroendocrine tumor, microvessel density, imaging, computed tomography, endoscopic ultrasound, vascularization, enhancement, washout,

#2693 The Distinctive Character of Micro-Vasculature and Immune Cell Infiltration in Cystic Pancreatic Neuroendocrine Tumors

Introduction: Hypervascularity is main character of pancreatic neuroendocrine tumors (PanNETs), cystic PanNET (CPanNET) are unique type of PanNETs for which the microenvironment remains unknown.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Gao H,

Keywords: pancreatic neuroendocrine tumors, cystic, microvascular density, microvascular integrity, tumor-associated macrophage,

#2261 Mechanisms of Main Pancreatic Duct Dilatation in Pancreatic Neuroendocrine Tumors (PanNETs): Radiopathologic Correlation

Introduction: Main pancreatic duct (MPD) dilatation, a frequent observation in cases with adenocarcinoma can also be observed in patients with PanNET.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Ronot M

Authors: Ronot M, Cros J, Faccinetto A, de Mestier L, Hentic O,

Keywords: Sclerozing PanNET, MRI, Main duct dilatation,